Total Syntheses of the Bilirubin Oxidation End Product Z-BOX C and its Isomeric Form Z-BOX D

Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB01117J, PaperDaniel Schulze, Juliane Traber, Marcel Ritter, Helmar G örls, Georg Pohnert, Matthias Westerhausen Oxidative degradation products of bilirubin (BOXes) are biologically highly active. The total synthesis of colorless (Z)-3-(5-(2-amino-2-oxoethylidene)-4-methyl-2-oxo-2,5-dihydro-1H-pyrrol-3-yl)propanoic acid (BOX C, 9) succeeds via a seven-step procedure with a total yield of... The content of this RSS Feed (c) The Royal Society of Chemistry

Source: RSC - Organic and Biomolecular Chemistry - June 12, 2019 Category: Molecular Biology Authors: Daniel Schulze Source Type: research