Facile Synthesis of Chiral ε-Sultams via Organocatalytic Aza-Friedel-Crafts Reaction

Org. Biomol. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9OB01158G, CommunicationZi-Biao Zhao, lei shi, Yaming Li, Fan-Jie Meng, Yong-Gui Zhou A facile enantioselective aza-Friedel-Crafts reaction of seven-membered cyclic N-sulfonylimines with naphthols was developed with cinchona alkaloid-based bifunctional organocatalyst, giving the chiral ε-sultams with up to 92% ee. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Organic and Biomolecular Chemistry - Category: Molecular Biology Authors: Source Type: research