Overlapping of irritable bowel syndrome with erosive esophagitis and the performance of Rome criteria in diagnosing IBS in a clinical setting.

Overlapping of irritable bowel syndrome with erosive esophagitis and the performance of Rome criteria in diagnosing IBS in a clinical setting. Mol Med Rep. 2019 May 23;: Authors: El-Salhy M, Gilja OH, Hatlebakk JG Abstract Irritable bowel syndrome (IBS) and gastroesophageal reflux disease (GERD) overlap. It is not clear whether GERD is caused by non‑erosive esophagitis, or erosive esophagitis. The Rome criteria are not widely used for the diagnosis of IBS in the clinic. In total, 1,489 IBS patients without red flags were included in the present retrospective study. They comprised of 1,331 females and 158 males with a mean age of 51 years. The diagnosis of IBS was verified by endoscopic and histopathological examinations. Whereas erosive esophagitis occurred in 97% of patients, only 66% had GERD symptoms. Endoscopy and histopathological examinations revealed that 1.4% of the IBS patients with diarrhea as the predominant symptom had other organic gastrointestinal diseases: 0.3% with celiac disease, 0.2% with Crohn's disease, 0.07% with ulcerative colitis, 0.6% with microscopic colitis, and 0.2% with colon cancer. Applying the Rome III criteria produced a sensitivity of 100% [95% confidence intervals (CI)=99.8‑100.0%] a specificity of 98.7% (95% CI=98.0‑99.2%), a positive likelihood ratio of 76.9%, and a negative likelihood ratio of 0%. IBS is associated with erosive esophagitis. Applying Rome III criteria without red flags and history, ...
Source: Molecular Medicine Reports - Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Related Links:

Publication date: Available online 11 August 2020Source: Journal of Oral BiosciencesAuthor(s): Sho Akashi, Takashi Nishida, Tomomi Mizukawa, Kazumi Kawata, Masaharu Takigawa, Seiji Iida, Satoshi Kubota
Source: Journal of Oral Biosciences - Category: Biomedical Science Source Type: research
Publication date: 1 December 2020Source: Carbohydrate Polymers, Volume 249Author(s): Younghan Song, Jin Young Seo, Hyungsup Kim, Kyung-Youl Baek
Source: Carbohydrate Polymers - Category: Biomedical Science Source Type: research
Publication date: Available online 11 August 2020Source: Carbohydrate PolymersAuthor(s): Dongdong Li, Xuan Gao, Xuechun Huang, Pingle Liu, Wei Xiong, Shengtao Wu, Fang Hao, He’an Luo
Source: Carbohydrate Polymers - Category: Biomedical Science Source Type: research
Publication date: Available online 11 August 2020Source: Carbohydrate PolymersAuthor(s): Sevil Vaghefi Moghaddam, Fatemeh Abedi, Effat Alizadeh, Behzad Baradaran, Nasim Annabi, Abolfazl Akbarzadeh, Soodabeh Davaran
Source: Carbohydrate Polymers - Category: Biomedical Science Source Type: research
Publication date: Available online 11 August 2020Source: Carbohydrate PolymersAuthor(s): Jingwen Luo, Tao Gong, Lixin Ma
Source: Carbohydrate Polymers - Category: Biomedical Science Source Type: research
Publication date: July 2020Source: Biomedical and Environmental Sciences, Volume 33, Issue 7Author(s): Fei Ran WEI, Li Lin XIONG, Wei LI, Xue Rong WANG, Xin HONG, Bao An CHEN
Source: Biomedical and Environmental Sciences - Category: Biomedical Science Source Type: research
NF-κB transcription factors, driven by the IRAK/IKK cascade, confer treatment resistance in pancreatic ductal adenocarcinoma (PDAC), a cancer characterized by near-universal KRAS mutation. Through reverse-phase protein array and RNA sequencing we discovered that IRAK4 also contributes substantially to MAPK activation in KRAS-mutant PDAC. IRAK4 ablation completely blocked RAS-induced transformation of human and murine cells. Mechanistically, expression of mutant KRAS stimulated an inflammatory, autocrine IL-1β signaling loop that activated IRAK4 and the MAPK pathway. Downstream of IRAK4, we uncovered TPL2 (also k...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
Cachexia, a devastating wasting syndrome characterized by severe weight loss with specific losses of muscle and adipose tissue, is driven by reduced food intake, increased energy expenditure, excess catabolism, and inflammation. Cachexia is associated with poor prognosis and high mortality and frequently occurs in patients with cancer, chronic kidney disease, infection, and many other illnesses. There is no effective treatment for this condition. Hypothalamic melanocortins have a potent and long-lasting inhibitory effect on feeding and anabolism, and pathophysiological processes increase melanocortin signaling tone, leadin...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
Publication date: Available online 9 August 2020Source: The Journal of Steroid Biochemistry and Molecular BiologyAuthor(s): María Julia Ferronato, Serrano Mercedes Nadal, Enrique Javier Arenas Lahuerta, Cristina Bernadó Morales, Giuliana Paolillo, Aliguer Alex Martinez-Sabadell, Marilina Mascaró, Cristian Vitale, Yagamare Fall, Joaquín Arribas, María Marta Facchinetti, Alejandro Carlos Curino
Source: The Journal of Steroid Biochemistry and Molecular Biology - Category: Biochemistry Source Type: research
Publication date: Available online 6 August 2020Source: Chemico-Biological InteractionsAuthor(s): Yoke Ying Tan, Pui Khee Yap, Griselda Loo Xin Lim, Meenu Mehta, Yinghan Chan, Sin Wi Ng, Deepak N. Kapoor, Poonam Negi, Krishnan Anand, Sachin Kumar Singh, Niraj Kumar Jha, Lay Cheng Lim, Thiagarajan Madheswaran, Saurabh Satija, Gaurav Gupta, Kamal Dua, Dinesh Kumar Chellappan
Source: Chemico Biological Interactions - Category: Biochemistry Source Type: research
More News: Acid Reflux | Cancer | Cancer & Oncology | Celiac Disease | Coeliac Disease | Colon Cancer | Colorectal Cancer | Crohn's Disease | Endoscopy | Erosive Esophagitis | Gastroenterology | Gastroesophageal Reflux Disease | GERD | Inflammatory Bowel Disease | Irritable Bowel Syndrome | Molecular Biology | Organic | Study | Ulcerative Colitis