[D-Ala2, D-Leu5] Enkephalin Improves Liver Preservation During Normothermic Ex  Vivo Perfusion

Meeting the metabolic demands of donor livers using normothermic ex  vivo liver perfusion (NEVLP) preservation technology is challenging. The delta opioid agonist [D-Ala2, D-Leu5] enkephalin (DADLE) has been reported to decrease the metabolic demand in models of ischemia and cold preservation. We evaluated the therapeutic potential of DADLE by investigating its abi lity to protect against oxidative stress and hepatic injury during normothermic perfusion.

Source: Journal of Surgical Research - May 5, 2019 Category: Surgery Authors: Eliza W. Beal, Jung-Lye Kim, Brenda F. Reader, Clifford Akateh, Katelyn Maynard, W. Kenneth Washburn, Jay L. Zweier, Bryan A. Whitson, Sylvester M. Black Tags: Transplantation/Immunology Source Type: research