Comparison of combined bipolar radiofrequency impedance-controlled endometrial ablation with levonorgestrel intrauterine system versus bipolar radiofrequency endometrial ablation alone in women with abnormal uterine bleeding

This study aims to evaluate the efficacy of the combination of bipolar radiofrequency impedance-controlled endometrial ablation (NovaSure®) and levonorgestrel intrauterine system (LNG-IUS, Mirena) placement in comparison with NovaSure® endometrial ablation alone in patients with abnormal uterine bleeding (AUB).DesignA propensity-score-matching study.SettingBeijing Tiantan Hospital, Capital Medical University, Beijing, China.PatientsA retrospective study was conducted on 246 patients with AUB, who underwent NovaSure® endometrial ablation with (NovaSure®+LNG-IUS) or without (NovaSure® group) LNG-IUS between January 2013 and August 2016. In order to overcome selection bias, propensity score matching was used to establish a 1:1 match between these two groups. Accordingly, 41 patients were included in each group.InterventionNovaSure® endometrial ablation, immediately followed by LNG-IUS insertion in the NovaSure®+LNG-IUS group, and NovaSure® endometrial ablation alone in the control group.Measurements and Main ResultsFollow-up assessments performed at post-ablation months 6, 12 and 24 revealed the following: the rate of amenorrhea (78.05% vs. 46.34%, 85.37% vs. 53.65%, and 87.80% vs. 58.54%, respectively; P
Source: Journal of Minimally Invasive Gynecology - Category: OBGYN Source Type: research

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