Precision Oncology in Sarcomas: Divide and Conquer Precision Oncology in Sarcomas: Divide and Conquer

How is next-generation sequencing changing the landscape of diagnosis and treatment of sarcoma?JCO Precision Oncology
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Hematology-Oncology Journal Article Source Type: news

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Authors: Alan S, Yilmaz E, Tecellioglu F, Akatli AN, Inci Coskun E, Gokce H PMID: 31195864 [PubMed - as supplied by publisher]
Source: Journal of Obstetrics and Gynaecology - Category: OBGYN Tags: J Obstet Gynaecol Source Type: research
We present here a case of relapsed HIV-related Kaposi Sarcoma (KS), manifesting as a plantar ulcer with underlying bone involvement in a patient with well-controlled HIV. Radiographic and magnetic resonance imaging of the patient’s right foot showed bone destruction suggestive of osteomyelitis. However, when a bone biopsy was done, this was consistent with KS, without any signs of bone infection. Patient was initially diagnosed with KS four years prior. He was successfully treated at the time with doxorubicin, radiation therapy, and began HIV therapy. At the time of the KS recurrence, his HIV viral load was undetecta...
Source: IDCases - Category: Infectious Diseases Source Type: research
Condition:   Sarcoma, Soft Tissue Intervention:   Drug: Olaratumab and Trabectedin Sponsor:   Grupo Espanol de Investigacion en Sarcomas Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
We report our single-institution, multidisciplinary experience of nearly 20 years of working on chest wall soft tissue sarcoma cases. The aim of this study was to evaluate clinical outcomes in patients with chest wall soft tissue sarcoma. Materials and Methods A retrospective review of 49 surgically treated patients with chest wall soft tissue sarcoma was conducted from 1997 to 2015. Results The median age of the patients was 57.0 years. There were 19 full-thickness and 30 partial-thickness resections. Reconstruction was warranted in 37 cases. Sarcomas were high grade in 31 (63.3%) and low grade in 18 (36.7%) cases. ...
Source: Annals of Plastic Surgery - Category: Cosmetic Surgery Tags: Reconstructive Surgery Source Type: research
We present the case of a 58-year-old African –American female who was initially diagnosed with having a chest wall lipoma. After re-evaluation, the lesion was consistent with an intercostal myxoma versus myxoid sarcoma. Preoperative imaging could not exclude malignancy. Given the diagnostic uncertainty, she underwent primary wide local resec tion and placement of polypropylene mesh for chest wall reconstruction. Histopathological examination revealed an intramuscular myxoma without sarcomatous changes arising from the 8th intercostal muscle bundle.
Source: General Thoracic and Cardiovascular Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
This study examines survival time in patients with small bowel tumors and determines its contributing factors. In this retrospective analytical study, the medical records of 106 patients with small bowel cancer (from 2006 to 2011) were investigated. The patients' data were extracted, including age, gender, clinical presentation, location of tumor, histological type, grade of tumor, site of metastasis, and type of treatment. The Kaplan-Meier test was used to estimate the overall survival time and the Log-rank test to compare the survival curves. The Cox regression was also used to evaluate the effect of the confounding vari...
Source: International Journal of Surgical Oncology - Category: Surgery Tags: Int J Surg Oncol Source Type: research
ConclusionDespite of the high sensitivity, antibodies are not conclusive for an accurate diagnosis. Molecular techniques were required to establish this entity with great implication in patient management. Complete assesment of undifferentiated sarcomas should include clinical/radiological correlation, histopathology, immunohistochemical staining and genetic confirmation.
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - Category: ENT & OMF Source Type: research
Publication date: July 2019Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Volume 128, Issue 1Author(s): Dr. Suma Sukumar, Prof. Hedley ColemanVitamin C, also known as ascorbic acid, is a co-factor in multiple enzymatic reactions including that of collagen synthesis. Due to the absence of the enzyme L-gulonolactone oxidase, humans are unable to synthesise ascorbic acid; hence it is recognised as an essential nutrient. Scurvy refers to the clinical presentation of a deficiency of ascorbic acid, which occurs as a result of inadequate dietary intake. It has long been considered an illness of historical...
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - Category: ENT & OMF Source Type: research
Liposarcoma(LS) is the most common soft-tissue sarcoma. The histological spectrum has a well-differentiated-liposarcoma(WDLS) and a more aggressive dedifferentiated-liposarcoma(DDLS). Advanced therapeutic strategies based on molecular mechanism are urgently needed, especially for DDLS. Previously, we reported that TIMP-1 (a member of tissue-inhibitor-of-metalloproteinase), with its receptor CD63 activates yes-associated protein (YAP) and transcriptional co-activator with PDZ binding motif (TAZ) to promote cancer cell proliferation.
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - Category: ENT & OMF Authors: Tags: #76 Source Type: research
Ewing's sarcoma (ES) is a malignant small round cell neoplasm primarily affects the bone. It was first described by James Ewing in 1921. ES accounts for 6-10% of all primary malignant bone tumors. It is most commonly found in children between 10-15 years of age. 1% to 2% of cases of ES affect the craniofacial bones. Only a few cases have been reported in the mandible. Here we report a case of EW in the mandible and the use of immuno-histochemistry and molecular studies to confirm its diagnosis.
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - Category: ENT & OMF Authors: Tags: #65 Source Type: research
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