Woman had her hip replaced at 28 after begging for the procedure unable to get out of bed

Loretta Hood, of Leicester, was born with a deformed hip which was operated on at the age of one. But through her 20s, her hip wore down and was told she was too young for a replacement.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news

Related Links:

In this study, we found that TLR1/TLR2 expression predicted favorable prognosis of lung cancer patients. In the related mice tumor model, TLR1/TLR2 activation by synthetic bacterial lipoprotein (BLP), a TLR1/2 agonist, greatly inhibited tumor growth and selectively decreased monocytic MDSCs (M-MDSCs). Furthermore, BLP treatment redirected M-MDSC differentiation towards M1 macrophage through JNK pathway, and thus blocked the suppressive activity of M-MDSCs in a TLR2-dependent manner. Therefore, our data demonstrated that TLR2 could be a promising biomarker and a potential immunotherapeutic target for lung cancer.
Source: Molecular Immunology - Category: Allergy & Immunology Source Type: research
Publication date: August 2019Source: Molecular Immunology, Volume 112Author(s): Elizabeth A. Bemis, Jill M. Norris, Jennifer Seifert, Ashley Frazer-Abel, Yuko Okamoto, Marie L. Feser, M. Kristen Demoruelle, Kevin D. Deane, Nirmal K. Banda, V. Michael HolersAbstractRheumatoid arthritis (RA) is a complex autoimmune disease with an etiology that is not yet well understood, disproportionally affects women and also varies in incidence and prevalence by population. The presence of anti-citrullinated protein antibodies (ACPA) is a highly specific biomarker for the diagnosis of clinically apparent RA. ACPA are also present in the ...
Source: Molecular Immunology - Category: Allergy & Immunology Source Type: research
Publication date: Available online 14 June 2019Source: Analytic Methods in Accident ResearchAuthor(s): Lai Zheng, Tarek Sayed, Mohamed EssaAbstractA Bayesian hierarchical modeling (BHM) approach is used to model non-stationary traffic conflict extremes of different sites together for crash estimation. The hierarchical structure has three layers, a data layer that is modeled with a generalized extreme value (GEV) distribution, a latent Gaussian process layer that relates parameters of GEV to covariates and the unobserved heterogeneity, and a prior layer with prior distributions to characterize the latent process. The propos...
Source: Analytic Methods in Accident Research - Category: Accident Prevention Source Type: research
Publication date: Available online 14 June 2019Source: Stem Cell ResearchAuthor(s): Nupur Bhargava, Shashank Jaitly, Sangam Giri Goswami, Suman Jain, Debojyoti Chakraborty, Sivaprakash RamalingamAbstractSickle cell disease (SCD) is an autosomal recessive disorder caused by a mutation in β-globin (HBB) gene. We have generated an induced pluripotent stem cell (iPSC) line, IGIBi001-A from an Indian sickle cell patient with a homozygous HBB gene mutation using Sendai virus reprogramming system. Characterization of IGIBi001-A showed that these iPSCs are transgene-free and expressed pluripotent stem cell markers. They had a...
Source: Stem Cell Research - Category: Stem Cells Source Type: research
Publication date: Available online 14 June 2019Source: Stem Cell ResearchAuthor(s): Nutnicha Tantarungsee, Zaukir Bostan Ali, Rungtip Soi-ampornkul, Chuda Rujitharanawong, Chanika Subchookul, Alisa Ritthaphai, Bootsakorn Boonkaew, Methichit Wattanapanitch, Kanchalit Thanomkitti, Daranporn Triwongwaranat, Chinnavuth Vatanashevanopakorn, Rattapon ThuangtongAbstractAn induced pluripotent stem cell (iPSC) line, MUSIi010-A, was established by Sendai virus (SeV) transduction of scalp fibroblasts from a 59-year-old male with androgenetic alopecia (AGA). Pluripotency of the iPSC line was verified by immunofluorescence staining of ...
Source: Stem Cell Research - Category: Stem Cells Source Type: research
Authors: Malergue MC, Ohanessian A, Zannis K, Bruneval P, Ennezat PV PMID: 31199198 [PubMed - as supplied by publisher]
Source: Acta Cardiologica - Category: Cardiology Tags: Acta Cardiol Source Type: research
This report could be used to provide guidance for both practical and economical approaches. PMID: 31190617 [PubMed - as supplied by publisher]
Source: Acta Cardiologica - Category: Cardiology Tags: Acta Cardiol Source Type: research
Authors: Lee JH, Nam JH, Park JS, Lee DH PMID: 31190481 [PubMed - as supplied by publisher]
Source: Korean Circulation Journal - Category: Cardiology Tags: Korean Circ J Source Type: research
CONCLUSIONS: These data provide the current PCI practice pattern with the use of FFR and IVUS in intermediate lesion. More common use of FFR for intermediate lesion should be encouraged. PMID: 31190480 [PubMed - as supplied by publisher]
Source: Korean Circulation Journal - Category: Cardiology Tags: Korean Circ J Source Type: research
CONCLUSIONS: Separate examination of control rates demonstrated different sex- and age-differential trends, which would have been overlooked in combined control rates. PMID: 31190479 [PubMed - as supplied by publisher]
Source: Korean Circulation Journal - Category: Cardiology Tags: Korean Circ J Source Type: research
More News: Health