Structural diversity of coiled coils in protein fibers of the bacterial cell envelope.

Structural diversity of coiled coils in protein fibers of the bacterial cell envelope.
Int J Med Microbiol. 2019 Jun 03;:
Authors: Hernandez Alvarez B, Bassler J, Lupas AN
Abstract
The cell envelope of bacteria shows great diversity in architecture and composition, to a large extent due to its proteome. Proteins localized to the cell envelope, whether integrally embedded in the membrane, membrane-anchored, or peripherally associated as part of a macromolecular complex, often form elongated fibers, in which coiled coils represent a prominent structural element. These coiled-coil segments show a surprising degree of structural variability, despite being shaped by a small number of simple biophysical rules, foremost being their geometry of interaction referred to as 'knobs-into-holes'. Here we will review this diversity, particularly as it has emerged over the last decade.
PMID: 31182277 [PubMed - as supplied by publisher]

Source: International Journal of Medical Microbiology - June 2, 2019 Category: Microbiology Authors: Hernandez Alvarez B, Bassler J, Lupas AN Tags: Int J Med Microbiol Source Type: research