Variants in STAT4 Associated With Cure of Chronic HBV Infection in HBeAg-positive Patients Treated With Pegylated Interferon-alpha

Variants in STAT4 (rs7574865) have been associated with seroconversion to hepatitis B e antigen (HBeAg) and reduction in levels of hepatitis B virus (HBV) DNA in patients with chronic infection treated with interferon alpha (IFNA). We evaluated the associations among rs7574865, loss of HB surface antigen (HBsAg, a marker of functional cure of HBV infection), and response to treatment with pegylated IFNA (PegIFN) or nucleos(t)ide analogues (NUCs) in HBeAg-positive patients with chronic HBV infection.

Source: Clinical Gastroenterology and Hepatology - April 27, 2019 Category: Gastroenterology Authors: Haitao Chen, Jian Sun, Bin Zhou, Qing Xie, Xier Liang, Rong Fan, Carly Conran, Jianfeng Xu, Yuan Ji, Xinxin Zhang, Li Sun, Jidong Jia, Guiqiang Wang, Jinlin Hou, De-Ke Jiang Source Type: research