Higenamine, a Dual Agonist for β 1- and β 2-Adrenergic Receptors Identified by Screening a Traditional Chinese Medicine Library

In conclusion, we found an herbal compound, higenamine, to be a dual agonist for β
1/β
2-adrenergic receptors with no preference in stimulating the Gs and Gi pathways in β
2-adrenergic receptor signaling. Our results elucidated not only the target of higenamine to explain its pharmacological effect in treating chronic heart failure, but also the mechanisms of its cardiac toxicity. [...] Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text

Source: Planta Medica - June 10, 2019 Category: Drugs & Pharmacology Authors: Chen, Yanmin Guo, Bujing Zhang, Hongda Hu, Lihong Wang, Jue Tags: Original Papers Source Type: research