Variable G protein determinants of GPCR coupling selectivity [Pharmacology]
G protein-coupled receptors (GPCRs) activate four families of heterotrimeric G proteins, and individual receptors must select a subset of G proteins to produce appropriate cellular responses. Although the precise mechanisms of coupling selectivity are uncertain, the Gα subunit C terminus is widely believed to be the primary determinant recognized by...
Source: Proceedings of the National Academy of Sciences - Category: Science Authors: Najeah Okashah, Qingwen Wan, Soumadwip Ghosh, Manbir Sandhu, Asuka Inoue, Nagarajan Vaidehi, Nevin A. Lambert Tags: Biological Sciences Source Type: research