Analysis of phototoxin taste closely correlates nucleophilicity to type 1 phototoxicity [Neuroscience]

Pigments often inflict tissue-damaging and proaging toxicity on light illumination by generating free radicals and reactive oxygen species (ROS). However, the molecular mechanism by which organisms sense phototoxic pigments is unknown. Here, we discover that Transient Receptor Potential Ankyrin 1-A isoform [TRPA1(A)], previously shown to serve as a receptor for...

Source: Proceedings of the National Academy of Sciences - June 10, 2019 Category: Science Authors: Eun Jo Du, Tae Jung Ahn, Hwajin Sung, HyunJi Jo, Hyung-Wook Kim, Seong-Tae Kim, KyeongJin Kang Tags: Biological Sciences Source Type: research