Single-cell RNA sequencing unveils the shared and the distinct cytotoxic hallmarks of human TCRV{delta}1 and TCRV{delta}2 {gamma}{delta} T lymphocytes [Immunology and Inflammation]
γδ T lymphocytes represent ∼1% of human peripheral blood mononuclear cells and even more cells in most tissues of vertebrates. Although they have important anticancer functions, most current single-cell RNA sequencing (scRNA-seq) studies do not identify γδ T lymphocytes because their transcriptomes at the single-cell level are unknown. Here we...
Source: Proceedings of the National Academy of Sciences - Category: Science Authors: Gabriele Pizzolato, Hannah Kaminski, Marie Tosolini, Don–Marc Franchini, Frederic Pont, Frederic Martins, Carine Valle, Delphine Labourdette, Sarah Cadot, Anne Quillet–Mary, Mary Poupot, Camille Laurent, Loic Ysebaert, Serena Meraviglia, Franc Tags: PNAS Plus Source Type: research