Coupling of COPII vesicle trafficking to nutrient availability by the IRE1{alpha}-XBP1s axis [Cell Biology]

The cytoplasmic coat protein complex-II (COPII) is evolutionarily conserved machinery that is essential for efficient trafficking of protein and lipid cargos. How the COPII machinery is regulated to meet the metabolic demand in response to alterations of the nutritional state remains largely unexplored, however. Here, we show that dynamic changes...

Source: Proceedings of the National Academy of Sciences - June 10, 2019 Category: Science Authors: Lin Liu, Jie Cai, Huimin Wang, Xijun Liang, Qian Zhou, Chenyun Ding, Yuangang Zhu, Tingting Fu, Qiqi Guo, Zhisheng Xu, Liwei Xiao, Jing Liu, Yujing Yin, Lei Fang, Bin Xue, Yan Wang, Zhuo-Xian Meng, Aibin He, Jian-Liang Li, Yong Liu, Xiao-Wei Chen, Zhenji Tags: PNAS Plus Source Type: research