Mucoid Pseudomonas aeruginosa alters sputum viscoelasticity in patients with non-cystic fibrosis bronchiectasis

and aim: Pseudomonas aeruginosa could acquire a mucoid phenotype due to mutations in mucA (mucoid Pseudomonas aeruginosa - mPA) that is a hallmark of poor prognosis in patients with bronchiectasis. Despite the higher prevalence of Pseudomonas aeruginosa in bronchiectasis, how mPA and non-mucoid Pseudomonas aeruginosa (non-mPA) phenotypes could affect viscoelastic properties of sputum is unknown. Our aim was to determine the relationship between Pseudomonas aeruginosa phenotypes isolation, the viscoelastic properties of sputum and the clinical outcomes in patients with bronchiectasis.

Source: Respiratory Medicine - June 10, 2019 Category: Respiratory Medicine Authors: Victoria Alcaraz-Serrano, Laia Fern ández-Barat, Giulia Scioscia, Joan Llorens-Llacuna, Elena Gimeno-Santos, Beatriz Herrero-Cortina, Nil Vàzquez, Jordi Puig de la Bellacasa, Albert Gabarrús, Rosanel Amaro-Rodriguez, Rosario Menendez, Antoni Torres Source Type: research