Oral Novo Nordisk diabetes drug poses no more heart risk than placebo: study

An experimental oral form of a Novo Nordisk drug for type 2 diabetes posed no greater risk of serious heart problems or death than a placebo in patients at high risk for such complications, according to data from a large study presented on Tuesday.
Source: Reuters: Health - Category: Consumer Health News Tags: healthNews Source Type: news

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Publication date: July 2019Source: Arabian Journal of Chemistry, Volume 12, Issue 5Author(s): Rina Soni, Sunil Dutt Durgapal, Shubhangi S. Soman, John J GeorrgeAbstractDPP-IV inhibitors have been immersed as promising pathway to treat Type 2 diabetes. Here we have reported designing of coumarin derivatives as DPP-IV inhibitors. Designed compounds have been studied for their binding with DPP-IV enzyme through molecular docking followed by synthesis. All synthesized compounds have been fully characterized and screened for DPP-IV inhibition activity. Two compounds showed very good inhibition at 10 μM concentration.
Source: Arabian Journal of Chemistry - Category: Chemistry Source Type: research
Authors: Mineoka Y, Ishii M, Hashimoto Y, Yamashita A, Nakamura N, Fukui M Abstract Diabetic foot ulcer is a major complication in patients with diabetes. Platelet-lymphocyte ratio (PLR) has been reported to have a predictive effect to some diabetic complications in recent years. However, it has not been fully elucidated about the relationship between diabetic foot risk or diabetic foot ulcer and PLR in patients with type 2 diabetes. Therefore, we aimed to evaluate this relationship. In this cross-sectional study, we evaluated the relationships between patient's diabetic foot risk with the criteria of the Internati...
Source: Endocrine Journal - Category: Endocrinology Tags: Endocr J Source Type: research
In this study, we evaluated ability of Pterostilbene (PTS), a methoxylated analog of resveratrol and a known antioxidant, to reverse palmitic acid (PA)-mediated IR in HepG2 cells. PTS prevented ROS formation and subsequent oxidative lipid damage by reducing the expression of NADPH oxidase 3 (NOX3) in PA treated HepG2 cells. Hepatic glucose production was used as a measure of IR and PTS reversed PA-mediated increase in hepatic glucose production by reducing expression of genes coding for gluconeogenic enzymes namely glucose-6-phosphatase (G6Pase), phosphoenolpyruvate carboxykinase (PEPCK) and pyruvate carboxylase (PC); and ...
Source: Free Radical Research - Category: Research Tags: Free Radic Res Source Type: research
In this study, we investigated the association between the solute carrier family 2 facilitated glucose transporter member 1 (SLC2A1) HaeIII polymorphism and DN in Korean patients with type 2 diabetes mellitus (T2DM) according to disease duration. METHODS: A total of 846 patients with T2DM (mean age, 61.3 ± 12.3 years; mean duration of T2DM, 10.3 ± 7.9 years; 55.3% men) who visited the Chungbuk National University Hospital were investigated. The HaeIII polymorphism of the SLC2A1 gene was determined by the real time polymerase chain reaction method. Genotyping results were presented as GG, AG, or AA. A subg...
Source: Journal of Korean Medical Science - Category: Biomedical Science Tags: J Korean Med Sci Source Type: research
ConclusionSerum ferritin is not associated with glucose homeostasis in the early years following a GDM pregnancy.
Source: Canadian Journal of Diabetes - Category: Endocrinology Source Type: research
The U.S. Food and Drug Administration (FDA) has determined that recent data for rosiglitazone-containing drugs, such as Avandia, Avandamet, Avandaryl, and generics, do not show an increased risk of heart attack compared to the standard type 2 diabetes medicines metformin and sulfonylurea.
Source: FDA Center for Drug Evaluation and Research - What's New - Category: Drugs & Pharmacology Authors: Source Type: news
TYPE 2 diabetes affects more than one million people and many of them are unaware they have the condition as they have not been diagnosed. A certain smell in your urine could mean you are at risk. Have you noticed this smell?
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
ConclusionHigher levels of glutamate and lower levels of glutamine were associated with increased risk of T2D in a Spanish population at high risk for CVD. Mediterranean diet might mitigate the association between the imbalance of glutamine and glutamate and T2D risk.This trial is registered at http://www.controlled-trials.com, ISRCTN35739639.Graphical abstract
Source: Nutrition, Metabolism and Cardiovascular Diseases - Category: Nutrition Source Type: research
Publication date: Available online 7 May 2019Source: Canadian Journal of DiabetesAuthor(s): Bhavadharini Balaji, Anjana Ranjit Mohan, Pradeepa Rajendra, Deepa Mohan, Uma Ram, Mohan ViswanathanAbstractOne in every 4 pregnancies is affected by hyperglycemia, of which 90% is gestational diabetes mellitus (GDM). Women with GDM are at a high risk of developing both short- and long-term complications. Various studies have shown the heightened risk of type 2 diabetes among women with GDM. Despite clear evidence from published literature about the substantial risk that GDM imposes on women after delivery, rates of postpartum follo...
Source: Canadian Journal of Diabetes - Category: Endocrinology Source Type: research
The TODAY-2 study showed that kids with type 2 diabetes have accelerating rates of cardiovascular, renal, eye, and nerve disease.Medscape Diabetes &Endocrinology
Source: Medscape Diabetes Headlines - Category: Endocrinology Tags: Diabetes & Endocrinology Commentary Source Type: news
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