Metabolic characterization of diabetic retinopathy: An 1H-NMR-based metabolomic approach using human aqueous humor

Publication date: Available online 10 June 2019Source: Journal of Pharmaceutical and Biomedical AnalysisAuthor(s): Huiyi Jin, Bijun Zhu, Xia Liu, Jing Jin, Haidong ZouAbstractPatients with a long duration of diabetes mellitus (DM) usually have accompanied complications such as diabetic retinopathy (DR), which is a leading cause of blindness and visual impairment among working-age persons in developed countries; nevertheless, some patients have no complications. Thus, various studies, including genomic, transcriptomic, and proteomic studies, have been conducted to identify potential biomarkers for predicting DR and to reveal the underlying disease mechanism. Although metabolomics could be a powerful tool for characterizing aqueous eye fluids and revealing the metabolic signatures of common ocular diseases such as DR, studies about its relationship with DR are limited. Moreover, to our knowledge, no previous study has applied a metabolomic approach to investigate the aqueous humor in DR.Therefore, we performed an NMR-based metabolomic study of the aqueous humor of patients with DM and cataract (DM, n = 13), DR and cataract (DR, n = 14), and senile cataract (CON, n = 7) to investigate the metabolic alterations accompanying the development of DR. Principal component analysis, average change analysis, and heatmap analysis revealed that lactate, succinate, 2-hydroxybutyrate, asparagine, dimethylamine, histidine, threonine, and glutamine wer...
Source: Journal of Pharmaceutical and Biomedical Analysis - Category: Drugs & Pharmacology Source Type: research

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Authors: Udler MS, McCarthy MI, Florez JC, Mahajan A Abstract Over the last decade, there have been substantial advances in the identification and characterization of DNA sequence variants associated with individual predisposition to type 1 and type 2 diabetes. As well as providing insights into the molecular, cellular and physiological mechanisms involved in disease pathogenesis, these risk variants, when combined into a polygenic score, capture information on individual patterns of disease predisposition that have the potential to influence clinical management. In this review, we describe the various opportunitie...
Source: Endocrine Reviews - Category: Endocrinology Tags: Endocr Rev Source Type: research
Authors: Davis TM, Makepeace AE, Peters K, Colclough K, Davis WA PMID: 31321782 [PubMed - as supplied by publisher]
Source: Medical Journal of Australia - Category: General Medicine Tags: Med J Aust Source Type: research
Authors: Lee JH Abstract Purpose: The study aimed to investigate the prevalence of hyperuricemia and its association with metabolic syndrome (MetS) and cardiometabolic risk factors (CMRFs) in Korean children and adolescents. Methods: This cross-sectional survey used data from the 7th Korea National Health and Nutrition Examination Survey (2016-2017), and 1,256 males and females aged 10-18 years were included. Hyperuricemia was defined when SUA levels were>6.6 mg/dL at 10-11 years of age (both sex), and>7.7 mg/dL for males at 12-18 years of age and>5.7 mg/dL for females at 12-18 years of age. MetS was d...
Source: Korean Journal of Pediatrics - Category: Pediatrics Tags: Korean J Pediatr Source Type: research
TYPE 2 diabetes affects over four million people in the UK and those numbers are growing everyday. Lifestyle plays a huge role in developing the condition and with obesity at an all time high, a new NHS backed app hopes to get Britons healthier and reduce their risk of developing the condition.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Authors: Sun L, Yu M, Zhou T, Zhang S, He G, Wang G, Gang X Abstract The incidence of diabetes mellitus has become a major public health concern due to lifestyle alterations. Moreover, the complications associated with diabetes mellitus deeply influence the quality of life of patients. Diabetic cardiomyopathy (DC) is a type of diabetes mellitus complication characterized by functional and structural damage in the myocardium but not accompanied by coronary arterial disease. Currently, diagnosing and preventing DC is still a challenge for physicians due to its atypical symptoms. For this reason, it is necessary to su...
Source: Molecular Medicine Reports - Category: Molecular Biology Tags: Mol Med Rep Source Type: research
Authors: Guo X, Li J, Wang Q, Shu Y, Wang J, Chen L, Zhang H, Shi Y, Yang J, Lu F, Jiang L, Qu C, Gong B Abstract Retinitis pigmentosa (RP) is a leading cause of inherited blindness characterized by progressive loss of retinal photoreceptor cells. The present study aimed to identify the causative gene mutations in two Chinese families with autosomal recessive retinitis pigmentosa (arRP). Two Chinese consanguineous arRP families (RP‑2284 and RP‑2360) were recruited in this study, involving totally three affected and 25 unaffected members. All the affected members underwent a complete ophthalmic ex...
Source: Molecular Medicine Reports - Category: Molecular Biology Tags: Mol Med Rep Source Type: research
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Source: Molecular Medicine Reports - Category: Molecular Biology Tags: Mol Med Rep Source Type: research
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Source: Molecular Medicine Reports - Category: Molecular Biology Tags: Mol Med Rep Source Type: research
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Source: Future Medicine: Biomarkers in Medicine - Category: Internal Medicine Tags: Biomark Med Source Type: research
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Source: Biomedical Signal Processing and Control - Category: Biomedical Science Source Type: research
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