Randomized Placebo-Controlled Trial Evaluating the Ophthalmic Safety of Single-Dose Tafenoquine in Healthy Volunteers

ConclusionThere was no evidence of any pharmacodynamic effect of 300-mg single-dose tafenoquine on the retina or any short-term clinically relevant effects on ophthalmic safety. This clinical trial is registered with ClinicalTrials.gov (identifier: NCT02658435).
Source: Drug Safety - Category: Drugs & Pharmacology Source Type: research

Related Links:

(Deakin University) Researchers have narrowed down the malaria proteins and disease-fighting antibodies that could be used to develop a vaccine against the most severe forms of malaria.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
ira Nubia Boechat Based on medicinal chemistry tools, new compounds for malaria treatment were designed. The scaffolds of the drugs used to treat malaria, such as chloroquine, primaquine, amodiaquine, mefloquine and sulfadoxine, were used as inspiration. We demonstrated the importance of quinoline and non-quinoline derivatives in vitro with activity against the W2 chloroquine-resistant (CQR) Plasmodium falciparum clone strain and in vivo against Plasmodium berghei-infected mouse model. Among the quinoline derivatives, new hybrids between chloroquine and sulfadoxine were designed, which gave rise to an important proto...
Source: Molecules - Category: Chemistry Authors: Tags: Review Source Type: research
The objective of this study was to evaluate the in vitro antiplasmodial properties against malaria parasite in 15 plants mentioned in Indian traditional medicine texts.MethodsIn vitro antiplasmodial activity of methanolic extracts obtained from Indian traditional medicinal plants was evaluated on Plasmodium falciparum of FCK2 and INDO strains using schizont maturation inhibition assay and parasite lactate dehydrogenase inhibition assay.ResultsMethanolic extracts of Adhatoda zeylanica, Embelia ribes, Piper nigrum and Plumbago zeylanica exhibited more than 50% inhibition in both the stains in schizont maturation inhibition a...
Source: Journal of Integrative Medicine - Category: Complementary Medicine Source Type: research
In conclusion, while travelling to endemic countries, people should be informed about the importance of malaria prophylaxis and prophylaxis should be commenced immediately and continued appropriately. Additionally, malaria should always be considered in the differential diagnosis of high fever for the patients who admitted to the hospital with a travelling history to these countries. PMID: 31709945 [PubMed - in process]
Source: Mikrobiyoloji Bulteni - Category: Microbiology Tags: Mikrobiyol Bul Source Type: research
By Alice Rwema Iribagiza, Communications Officer, Ingobyi Nurse Esther at work. Photo credit: IntraHealth International.November 12, 2019Esther Mukahabiyambere is one of 326 district-based mentors trained on the Integrated Management of Childhood Illness (IMCI) approach. Through the USAID-fundedIngobyi Activity, health workers are using IMCI in Rwanda to prevent and treat pneumonia, diarrhea, malnutrition, and malaria. The project equips health care providers with clinical knowledge, skills, and attitudes to improve the quality of care, helping the government of Rwanda reduce child mortality, particularly the managemen...
Source: IntraHealth International - Category: International Medicine & Public Health Authors: Tags: Maternal, Newborn, & Child Health Education Performance Quality of Care Nurses Source Type: news
[Radio Dabanga] Khartoum -Sudan has been facing various disease outbreaks in the past months, including cholera, dengue fever, Rift Valley fever (RVF), chikungunya, and malaria. The government and humanitarian partners actively responded to the outbreaks, the UN Office for the Coordination of Humanitarian Affairs (OCHA) reports. Most complaints reaching Radio Dabanga come from the western and eastern parts of the country.
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
(eLife) An autoimmune attack on uninfected red blood cells likely contributes to anaemia -- a shortage of red blood cells -- in people with malaria, according to a new study published in eLife.
Source: EurekAlert! - Infectious and Emerging Diseases - Category: Infectious Diseases Source Type: news
Anemia is a common complication of malaria which is characterized by the loss of infected and uninfected erythrocytes. In mice malaria models, clearance of uninfected erythrocytes is promoted by autoimmune anti-phosphatidylserine (PS) antibodies produced by T-bet+B-cells, which bind to exposed PS in erythrocytes, but the mechanism in patients is still unclear. InP. falciparum patients with anemia, we show that atypical memory FcRL5+T-bet+B-cells are expanded and associate with higher levels of anti-PS antibodies in plasma and with the development of anemia in these patients. No association of anti-PS antibodies or anemia w...
Source: eLife - Category: Biomedical Science Tags: Immunology and Inflammation Source Type: research
Drug resistance is one of the greatest challenges of malaria control programme in Mali. Recent advances in next-generation sequencing (NGS) technologies provide new and effective ways of tracking drug-resistan...
Source: Malaria Journal - Category: Infectious Diseases Authors: Tags: Research Source Type: research
Condition:   Pregnancy; HIV; Malaria Intervention:   Drug: Intermittent Preventive Therapy with Dihydroartemisinin-Piperaquine Sponsors:   Liverpool School of Tropical Medicine;   Kenya Medical Research Institute;   University of Malawi College of Medicine;   Kenya National AIDS & STI Control Programme;   KEMRI-Wellcome Trust Collaborative Research Program;   Centers for Disease Control and Prevention;   University of Copenhagen;   Universit...
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
More News: Clinical Trials | Drugs & Pharmacology | Malaria | Opthalmology | Study | Vitamin A