Cardiac Applications of Dual-Energy Computed Tomography

Computed tomography is an established tool in the assessment of cardiac anatomy and function. As demonstrated by single photon emission computed tomography, positron emission tomography, and magnetic resonance, the noninvasive evaluation of coronary hemodynamics is an important step in guiding clinical management. Nevertheless, no single modality has been shown to accurately quantify coronary artery stenosis, evaluate an atherosclerotic plaque’s composition for embolic risk stratification, and assess myocardial perfusion. Although not a novel technology, dual-energy computed tomography has undergone significant advancements that have increased interest in this modality’s potential clinical cardiac applications. Albeit still in the early stages of development, one can expect additional clinical studies to further develop this important tool for cardiac imaging as more institutions acquire dual-energy compatible scanners.
Source: Cardiology in Review - Category: Cardiology Tags: Review Articles Source Type: research

Related Links:

Abstract Cardiovascular diseases are the most common cause of death in patients over 60 years old. Imaging methods of a pivotal role in cardiological diagnostic processes are echocardiography, magnetic resonance, multi-row-detector computed tomography, coronary angiography, and radioisotope tests. In this paper, we summarize the techniques of nuclear medicine (positron emission tomography, single-photon emission computed tomography, radionuclide ventriculography) that could be implemented in the cardiovascular diagnostic algorithms. Despite being acknowledged and positioned in a few cardiological guidelines, these...
Source: Polish Heart Journal - Category: Cardiology Authors: Tags: Kardiol Pol Source Type: research
AbstractPurpose of ReviewThe most pertinent clinical question in post-coronary computed tomography angiography (CCTA) patients is the assessment of the physiological significance of an anatomically identified stenosis. The clinical application of radionuclide MPI using single-photon emission computed tomography (SPECT) versus positron emission tomography (PET) in the evaluation and management of patients with an inconclusive CCTA is reviewed using a case-based approach.Recent FindingsRecent evidence suggests that CCTA is the most sensitive non-invasive test to exclude angiographic CAD and may be an effective first-line tes...
Source: Current Cardiology Reports - Category: Cardiology Source Type: research
Conclusions: Perfusion normalization and functional recovery (as suggested by improved LVEF, WMSI and NYHA grading) precedes substrate normalization.
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Clinical Science (Poster Session) Source Type: research
Conclusions: All compound were successfully prepared. All final products exhibited high stability in human serum and saline, as well as selective uptake in cardiomyocyte cells in vitro. 18F-HX01 and 18F-HX06 display high and persistent cardiac uptake over 2 h with high myocardium-to-lung and myocardium-to-liver ratio in healthy mice in PET imaging, which were also observed in biodistribution studies. Advancement of these radiotracers for MPI imaging is currently underway.Fig 1. Synthesis route for the reference standards, precursors and radio-labeled products.Fig 2. Static PET imaging of 18F-HX01 in rat (30 mins post injec...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Cardiovascular Basic Science (Poster Session) Source Type: research
1163Objectives: Bronchopleural fistula (BPF) is a communication between the airway and the pleural space. An untreated fistula can interfere with ventilation and phonation. A nuclear medicine lung perfusion scan with SPECT can be an alternative means of diagnosis when conventional methods of diagnosis fail.Bronchopleural fistula (BPF) can be central or peripheral occurring after infection, rheumatic diseases, necrotizing pneumonia, empyema, interventions or bullous rupture. An untreated BPF carries high morbidity and mortality due to hampered ventilation or phonation, as well as, direct communication of mucus secretions fr...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Educational Exhibits Poster Session I Source Type: research
In this study, we aimed to evaluate the cerebral metabolism in patients with heart failure (HF) to determine the correlation between myocardial phenotypic characterization and cerebral metabolic activity. Methods: Eighty-three HF patients were prospectively enrolled. All participants underwent gated 99mTc-sestamibi single photon emission computed tomography (SPECT)/CT myocardial perfusion imaging, also cardiac and cerebral 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET)/CT. Fifteen healthy volunteers underwent cerebral FDG PET/CT imaging served as controls. Patients were stratified by extent of hibernating ...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Cardiovascular Council YIA Symposium Source Type: research
Conclusions: These cases suggest that 123I-IMP SPECT is more useful than anatomical imaging in the clinical diagnosis of anti-NMDA receptor encephalitis. Radiologists should be familiar with the MR and 123I-IMP SPECT imaging findings, clinical manifestations, etiology, and pathophysiology of anti-NMDA receptor encephalitis, as timely and correct diagnosis can ensure prompt, appropriate treatment and a better clinical course.
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Neurology & amp; Psychiatry (Poster Session) Source Type: research
451Objectives: Results of combined 99mTc-MIBI myocardial SPECT/CT (SPECT/CT) &18F-FDG-PET/CT (PET/CT) studies for cardiac sarcoidosis typically are based on a subjective visual impression of 18F perfusion pattern heterogeneity, often referred to as "patchiness." Our investigation was undertaken to determine whether there are any quantitative image metrics that correspond to 18F PET/CT &perfusion heterogeneity &abnormal SPECT/CT visual interpretation. Methods: 92 combined SPECT/CT &PET/CT studies were performed on 69 pts (21 female; 48 male; age = 58±9 yrs) with cardiac arrhythmias &/or non-...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Assessment of Image Quality and Quantitative Accuracy Source Type: research
Conclusions: Advanced age and cardiovascular risk factors are determinants of MPR assessed by dynamic stress 201Tl/rest 99mTc-tetrofosmin SPECT in patients with type 2 diabetes and stable coronary artery disease.
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Clinical Science (Poster Session) Source Type: research
ConclusionsLeft ventricular volumes and ejection fraction assessed via ultra-low-dose CZT-SPECT showed very good correlation with the values obtained by MRI. A moderate correlation was found for myocardial mass.
Source: Journal of Nuclear Cardiology - Category: Nuclear Medicine Source Type: research
More News: Anatomy | Cardiology | CT Scan | Heart | Perfusion | PET Scan | SPECT | Study