Parathyroid Hormone and Cardiac Electrophysiology: A Review

Calcium has long been known to be essential to cardiac electrical activity. Parathyroid hormone (PTH) is the main regulator of serum calcium and is central to calcium homeostasis. Although there are significant data linking parathyroid disease states with changes in cardiac electrophysiology, most data have focused on how PTH modulates serum calcium to produce these effects. Close scrutiny of early literature demonstrates that the relationship between PTH and electrocardiographic changes is not straightforward, and numerous studies have linked PTH to arrhythmia. Basic science research has demonstrated that there is a basis for a direct role of PTH on cardiac electrophysiology outside of its effect on serum calcium. Later studies in secondary hyperparathyroidism indicate that PTH disturbances could have important implications for broad categories of patients with cardiovascular disease. The current review summarizes the existing literature on PTH and electrophysiology based on clinical and basic science studies of various parathyroid states, providing directions for future study.
Source: Cardiology in Review - Category: Cardiology Tags: Review Articles Source Type: research

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Myocardial calcifications are often discovered incidentally and result from dystrophic or metastatic deposition of calcium1. Dystrophic calcification represents the sequalae of local tissue damage with necrosis, most commonly from myocardial ischemia. Unlike the prior, metastatic calcification is the result of abnormal calcium homeostasis; including renal failure, hyperparathyroidism, and vitamin D deficiency. Myocardial calcifications are not entirely a benign finding, since they can lead to heart failure, arrhythmias and sudden cardiac death2.
Source: The American Journal of Medicine - Category: General Medicine Authors: Tags: Clinical Communication to the Editor Source Type: research
Myocardial calcifications are often discovered incidentally and result from dystrophic or metastatic deposition of calcium.1 Dystrophic calcification represents the sequelae of local tissue damage with necrosis, most commonly from myocardial ischemia. Unlike dystrophic calcification, metastatic calcification is the result of abnormal calcium homeostasis, including renal failure, hyperparathyroidism, and vitamin D deficiency. Myocardial calcifications are not entirely a benign finding because they can lead to heart failure, arrhythmias, and sudden cardiac death.
Source: The American Journal of Medicine - Category: General Medicine Authors: Tags: Clinical Communication to the Editor Source Type: research
It is important to consider calcium and parathyroid hormone levels in patients with recurrent VT/VF without any obvious cause of arrhythmia. In similar cases to gain rhythm control using isoprenaline and do comprehensive molecular ‐genetic. Diagnosis and surgery in case of parathyroid adenoma may be needed to obtain definite arrhythmia control. AbstractIt is important to consider calcium and parathyroid hormone levels in patients with recurrent VT/VF without any obvious cause of arrhythmia. In similar cases to gain rhythm control using isoprenaline and do comprehensive molecular ‐genetic. Diagnosis and surgery in case ...
Source: Clinical Case Reports - Category: General Medicine Authors: Tags: CASE REPORT Source Type: research
Primary hyperparathyroidism is strongly associated with cardiovascular disease. It is related to hypertension, left ventricular hypertrophy, cardiac valvular abnormalities, arrhythmias, and heart failure. While primary hyperparathyroidism can lead to ventricular stiffness, coronary artery and valvular calcifications, we aim to investigate the effects of primary hyperparathyroidism on mortality and length of hospital stay in patients admitted for acute congestive heart failure exacerbation.
Source: Journal of Cardiac Failure - Category: Cardiology Authors: Tags: 381 Source Type: research
ConclusionMediacalcosis is a severe complication since it increases the risk of cardiovascular morbidity and mortality in hemodialysis patients, to this end, the individualization of entangled factors involved in its pathophysiology, will slow down or prevent its progression in the future.
Source: Archives of Cardiovascular Diseases Supplements - Category: Cardiology Source Type: research
Publication date: Available online 24 July 2019Source: Archives of Cardiovascular Diseases SupplementsAuthor(s): Djamila-Djahida Batouche, Kheireddine Kerboua, Nadia-Faiza benatta, Samia Benouaz, Rabia Okbani, Wahiba Berrachdi, Miloud Lahmer, Lynda Sadaoui, Fadela Benhamed, Z. MentouriObjectivesCardiovascular complications are the leading cause of death and morbidity in chronic hemodialysis patients. The purpose of this study was to identify the factors associated with major cardiovascular events in hemodialysis children.MethodsBi-centric study was carried out during in 2016 into two hemodialysis departments. We included h...
Source: Archives of Cardiovascular Diseases Supplements - Category: Cardiology Source Type: research
REDUCTION OF ARRHYTHMIAS IN PRIMARY HYPERPARATHYROIDISM, BY PARATHYROIDECTOMY, EVALUATED WITH 24 HOUR ECG MONITORING. Eur J Endocrinol. 2018 Jun 06;: Authors: Pepe J, Cipriani C, Curione M, Biamonte F, Colangelo L, Danese V, Cecchetti V, Sonato C, Ferrone F, Cilli M, Minisola S Abstract OBJECTIVE: Hypercalcemia may induce arrhythmias. There are no data on the prevalence of arrhythmias in primary hyperparathyroidism (PHPT) in daily life. Aim of the study was to investigate both the prevalence of arrhythmias in patients with PHPT compared to controls and the impact of parathyroidectomy, evaluated by 24 ...
Source: European Journal of Endocrinology - Category: Endocrinology Authors: Tags: Eur J Endocrinol Source Type: research
CONCLUSION: We report an original case of intoxication by dihydrotachysterol. The risk of hypercalcemia encountered with this molecule must be known. The close medical follow-up recommended in case of hypoparathyroidism seems to be particularly necessary in case of supplementation by this molecule. PMID: 29709532 [PubMed - as supplied by publisher]
Source: Nephrologie and Therapeutique - Category: Urology & Nephrology Authors: Tags: Nephrol Ther Source Type: research
Publication date: Available online 7 December 2017 Source:Revista Portuguesa de Cardiologia (English Edition) Author(s): Tatiana Guimarães, Miguel Nobre Menezes, Diogo Cruz, Sónia do Vale, Armando Bordalo, Arminda Veiga, Fausto J. Pinto, Dulce Brito Hypercalcemia is a known cause of heart rhythm disorders, but it is rarely associated with ventricular arrhythmias. The authors present the case of a 53-year-old man with ischemic and alcoholic dilated cardiomyopathy and severely reduced ejection fraction, with a cardiac resynchronization therapy-cardioverter-defibrillator (ICD) device, who was admitted to the em...
Source: Revista Portuguesa de Cardiologia - Category: Cardiology Source Type: research
Abstract Data on cardiovascular disease in primary hyperparathyroidism (PHPT) are controversial; indeed, at present, cardiovascular involvement is not included among the criteria needed for parathyroidectomy. Aim of this narrative review is to analyze the available literature in an effort to better characterize cardiovascular involvement in PHPT. Due to physiological effects of both parathyroid hormone (PTH) and calcium on cardiomyocyte, cardiac conduction system, smooth vascular, endothelial and pancreatic beta cells, a number of data have been published regarding associations between symptomatic and mild PHPT wi...
Source: European Journal of Endocrinology - Category: Endocrinology Authors: Tags: Eur J Endocrinol Source Type: research
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