Efficacy of Combination Therapy with Actinomycin D and Methotrexate in the Treatment of Low-Risk Gestational Trophoblastic Neoplasia

Conclusion: Combined ACT-D+MTX chemotherapy achieved overall better efficacy and showed less toxicity than ACT-D or MTX alone, and thus can be prioritized for the treatment of LR-GTN.Chemotherapy
Source: Chemotherapy - Category: Cancer & Oncology Source Type: research

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Publication date: Available online 23 September 2020Source: Gynecologic Oncology ReportsAuthor(s): Emily Du, Melissa Perez, Tabetha Harken, Jill H. Tseng
Source: Gynecologic Oncology Reports - Category: OBGYN Source Type: research
Conditions:   Gestational Trophoblastic Tumor;   Gestational Trophoblastic Neoplasia;   Stage I Gestational Trophoblastic Tumor;   Stage II Gestational Trophoblastic Tumor;   Stage III Gestational Trophoblastic Tumor;   Invasive Mole;   Choriocarcinoma Interventions:   Drug: Methotrexate;   Drug: Leucovorin;   Drug: Dactinomycin Sponsor:   xiang yang Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Publication date: Available online 17 September 2020Source: Journal of Vascular and Interventional RadiologyAuthor(s): Gretchen A. Ferber, Sarah Khoncarly, James J. Buchino, Janice D. McDaniel
Source: Journal of Vascular and Interventional Radiology - Category: Radiology Source Type: research
Publication date: Available online 8 September 2020Source: Gynecologic Oncology ReportsAuthor(s): Abigail Cain, Edward Kost, Kevin Hall, Keeley Bell, Erin Mankus, Amanda Murray, Georgia McCann
Source: Gynecologic Oncology Reports - Category: OBGYN Source Type: research
Publication date: Available online 8 September 2020Source: European Journal of Obstetrics &Gynecology and Reproductive BiologyAuthor(s): Murali Subbaiah, Ashwini Raj, Jayalakshmi Durairaj, Anish Keepanasseril
Source: European Journal of Obstetrics and Gynecology and Reproductive Biology - Category: OBGYN Source Type: research
Abstract OBJECTIVE: To analyze the reproductive outcomes of gestational trophoblastic neoplasia (GTN) patients who were cured only by floxuridine-based regimens. METHODS: This was a retrospective analysis of 464 patients who were treated with only floxuridine-based regimens at Peking Union Medical College Hospital between January 2002 and December 2013 and retained their reproductive ability. Their reproductive outcomes were analyzed. The factors affecting pregnancy intention were identified by logistic regression. RESULTS: Of the 464 patients (average age, 28.0 ± 5.7 years; median ...
Source: Gynecologic Oncology - Category: Cancer & Oncology Authors: Tags: Gynecol Oncol Source Type: research
To evaluate the role of hysteroscopy and ultrasound in early identification of gestational trophoblastic neoplasia (GTN) after molar evacuation.
Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology - Category: OBGYN Authors: Tags: Full length article Source Type: research
Caesarean scar pregnancy (CSP) is a rare complication of caesarean delivery and a special type of ectopic pregnancy. Gestational trophoblastic neoplasia (GTN) is an uncommon complication of pregnancy. Early di...
Source: BMC Pregnancy and Childbirth - Category: OBGYN Authors: Tags: Case report Source Type: research
CONCLUSIONS: No surgeries other than uterine evacuation and no chemotherapy regimens are recommended for such patients if they achieve satisfactory decreases in the level of hCG and gradual decrease or disappearance of pulmonary deportation nodules. Patients should be informed about the necessity of long-term follow-up. More collaborative international studies on this exceedingly rare condition may guide decisions regarding optimal management strategies. PMID: 32826456 [PubMed - as supplied by publisher]
Source: Chinese Medical Journal - Category: General Medicine Authors: Tags: Chin Med J (Engl) Source Type: research
To evaluate the ultrasound diagnostic rates of complete hydatidiform moles (CHM) and partial hydatidiform moles (PHM) in women presenting with a missed miscarriage, the clinical complications at diagnosis and the risk of gestational trophoblastic neoplasia (GTN) after surgical evacuation and to compare our findings with those of the published literature by completing a systematic review and meta-analysis
Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology - Category: OBGYN Authors: Tags: Full length article Source Type: research
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