The effects of lapatinib on cardiac repolarization: results from a placebo controlled, single sequence, crossover study in patients with advanced solid tumors

ConclusionsThese data show a relevant, treatment-related increase in QTcF after treatment with three doses of lapatinib 2000  mg. This study confirms the need for caution in patients with solid tumors treated with lapatinib, and who are concomitantly receiving drugs that are strong CYP3A inhibitors and/or prolong the QTc.
Source: Cancer Chemotherapy and Pharmacology - Category: Cancer & Oncology Source Type: research