Ascending Lipopolysaccharide-Induced Intrauterine Inflammation in Near-Term Rabbits Leading to Newborn Neurobehavioral Deficits

Conclusions: This is the first study using an ascending LPS-induced intrauterine inflammation model in rabbits, showing mostly transient hypertonia and mainly locomotor deficits in the kits. Not all proinflammatory cytokines are increased in the fetal brain following LPS administration. Changes in key tetrahydro ­biopterin biosynthetic enzymes possibly indicate different effects of the inflammatory insult.Dev Neurosci
Source: Developmental Neuroscience - Category: Neuroscience Source Type: research