Electrically conductive nanomaterials for cardiac tissue engineering.

Electrically conductive nanomaterials for cardiac tissue engineering.
Adv Drug Deliv Rev. 2019 Jun 06;:
Authors: Ashtari K, Nazari H, Ko H, Tebon P, Akhshik M, Akbari M, Alhosseini SN, Mozafari M, Mehravi B, Soleimani M, Ardehali R, Warkiani ME, Ahadian S, Khademhosseini A
Abstract
Patient deaths resulting from cardiovascular diseases are increasing across the globe, posing the greatest risk to patients in developed countries. Myocardial infarction, as a result of inadequate blood flow to the myocardium, results in irreversible loss of cardiomyocytes which can lead to heart failure. A sequela of myocardial infarction is scar formation that can alter the normal myocardial architecture and result in arrhythmias. Over the past decade, a myriad of tissue engineering approaches has been developed to fabricate engineered scaffolds for repairing cardiac tissue. This paper highlights the recent application of electrically conductive nanomaterials (carbon and gold-based nanomaterials, electroactive polymers) to the development of scaffolds for cardiac tissue engineering. Moreover, this work summarizes the effects of these nanomaterials on cardiac cell behavior such as proliferation and migration, as well as cardiomyogenic differentiation in stem cells.
PMID: 31176755 [PubMed - as supplied by publisher]

Source: Advanced Drug Delivery Reviews - June 5, 2019 Category: Drugs & Pharmacology Authors: Ashtari K, Nazari H, Ko H, Tebon P, Akhshik M, Akbari M, Alhosseini SN, Mozafari M, Mehravi B, Soleimani M, Ardehali R, Warkiani ME, Ahadian S, Khademhosseini A Tags: Adv Drug Deliv Rev Source Type: research