Molecular Imaging in Ischemic Heart Disease

AbstractPurpose of ReviewThe purpose of this paper is to review current and new modalities to image key biological processes in ischemic heart disease and after myocardial infarction non-invasively.Recent FindingsNew imaging targets have been developed to detect and quantify myocardial damage after ischemia. Although positron emission tomography (PET) has been leading the development of new probes in the past, continuous improvements of magnetic resonance imaging (MRI) together with the development of new novel MRI contrast agents opens new research avenues including the combination of both PET and MRI to obtain anatomic, functional, and molecular information simultaneously, which is not possible from a single imaging session.SummaryThis review summarizes the state of art of non-invasive molecular imaging of the myocardium during ischemia and after myocardial infarction using PET and MRI. We also describe the different contrast agents that have been developed to image the different phases of cardiac healing and the biological processes associated with each of those phases. Importantly, here we focus on imaging of inflammation as it is the key biological process that orchestrates clearance of dead cells, tissue remodeling, cardiac repair, and future outcome. We also focus on clinical translation of some of the novel contrast agents that have been tested in patients and discuss the need for larger, multi-center patient studies to fully validate the applicability of new imaging ...
Source: Current Cardiovascular Imaging Reports - Category: Radiology Source Type: research

Related Links:

ConclusionsIn patients with LMCA disease, we have identified no significant interaction between the acuity of clinical indication and the relative treatment effect of PCI versus CABG on 10-year clinical outcomes.
Source: American Heart Journal - Category: Cardiology Source Type: research
Abstract Coronary heart disease (CHD) remains a major cause of mortality with a huge economic burden on healthcare worldwide. Here, we conducted a systematic review to investigate the efficacy and safety of Chinese herbal medicine (CHM) for CHD based on high-quality randomized controlled trials (RCTs) and summarized its possible mechanisms according to animal-based researches. 27 eligible studies were identified in eight database searches from inception to June 2018. The methodological quality was assessed using seven-item checklist recommended by Cochrane Collaboration. All the data were analyzed using Rev-Man 5....
Source: Pharmacological Reviews - Category: Drugs & Pharmacology Authors: Tags: Front Pharmacol Source Type: research
Publication date: Available online 20 August 2019Source: Anaesthesia &Intensive Care MedicineAuthor(s): Amanda Zacharzewski, Ross MacnabAbstractCardiac disease is a significant cause of maternal mortality. In the UK in the last maternal mortality report, it was the leading cause of indirect maternal deaths (2.39 deaths per 100,000 maternities). The overall rate of maternal mortality from cardiac disease has significantly increased over the last three decades, with this increase being mostly attributable to deaths from ischaemic heart disease, myocardial infarction and peripartum cardiomyopathy. Conditions such as pulmo...
Source: Anaesthesia and intensive care medicine - Category: Anesthesiology Source Type: research
Experts have long thought that an ex-smoker's risk of heart attack, stroke, heart failure or death from heart disease returns to normal within five years.
Source: WebMD Health - Category: Consumer Health News Source Type: news
Publication date: Available online 19 August 2019Source: Canadian Journal of DiabetesAuthor(s): Lucas C. Godoy, Caio A.M. Tavares, Michael E. FarkouhAbstractPatients with diabetes (DM) are at increased risk for developing coronary artery disease (CAD). Choosing the optimal revascularization strategy, i.e. coronary artery bypass grafting – CABG – or percutaneous coronary intervention – PCI, may be difficult in this population. A large body of evidence suggests that, for patients with DM and stable multivessel ischemic heart disease, CABG is usually superior to PCI, leading to lower rates of all-cause morta...
Source: Canadian Journal of Diabetes - Category: Endocrinology Source Type: research
We examined blood DNA methylation in relation to incident CHD across multiple prospective cohorts. METHODS: Nine population-based cohorts from the United States and Europe profiled epigenome-wide blood leukocyte DNA methylation using the Illumina Infinium 450k microarray, and prospectively ascertained CHD events including coronary insufficiency/unstable angina, recognized myocardial infarction, coronary revascularization, and coronary death. Cohorts conducted race-specific analyses adjusted for age, sex, smoking, education, body mass index, blood cell type proportions, and technical variables. We conducted fixed-effec...
Source: Circulation - Category: Cardiology Authors: Tags: Circulation Source Type: research
Pioneer UK surgeon Sir Terence English says adapted organs could transform treatmentAdapted pig hearts could be transplanted into patients within three years, according to a report citing the surgeon who pioneered heart transplantation in the UK.On the 40th anniversary of the first successful heart transplant, Sir Terence Englishtold The Sunday Telegraph that his protege from that operation would try to replace a human kidney with a pig ’s this year.Continue reading...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Medical research Heart attack Heart disease Science Society UK news Source Type: news
An almost epidemic number of people are actually suffering from ischemic heart disease (IHD), making this condition the leading cause of death worldwide [1]. According to the projection of the World Health Organization, by 2030, over 10 million deaths (13.4% of global deaths) would be attributable to IHD.
Source: International Journal of Cardiology - Category: Cardiology Authors: Tags: Editorial Source Type: research
FRIDAY, Aug. 16, 2019 -- Continuous positive airway pressure (CPAP) treatment of obstructive sleep apnea can ease depression in people with heart disease, according to a groundbreaking new study. " Patients who have had a stroke or heart attack are...
Source: - Daily MedNews - Category: General Medicine Source Type: news
ConclusionThe mean cost per patient shows that PCI is an expensive procedure in Mexico. A lack of subsidies for surgical equipment places a high economic burden on the patient and represents a barrier of access for a vulnerable population that likely increases mortality and morbidity rates in those patients unable to pay for treatment and a potential high burden of debt for those who do pay.
Source: Value in Health Regional Issues - Category: International Medicine & Public Health Source Type: research
More News: Cardiology | Cardiovascular | Gastroschisis Repair | Heart | Heart Attack | Heart Disease | Molecular Biology | MRI Scan | PET Scan | Radiology | Study