Molecular Imaging in Ischemic Heart Disease

AbstractPurpose of ReviewThe purpose of this paper is to review current and new modalities to image key biological processes in ischemic heart disease and after myocardial infarction non-invasively.Recent FindingsNew imaging targets have been developed to detect and quantify myocardial damage after ischemia. Although positron emission tomography (PET) has been leading the development of new probes in the past, continuous improvements of magnetic resonance imaging (MRI) together with the development of new novel MRI contrast agents opens new research avenues including the combination of both PET and MRI to obtain anatomic, functional, and molecular information simultaneously, which is not possible from a single imaging session.SummaryThis review summarizes the state of art of non-invasive molecular imaging of the myocardium during ischemia and after myocardial infarction using PET and MRI. We also describe the different contrast agents that have been developed to image the different phases of cardiac healing and the biological processes associated with each of those phases. Importantly, here we focus on imaging of inflammation as it is the key biological process that orchestrates clearance of dead cells, tissue remodeling, cardiac repair, and future outcome. We also focus on clinical translation of some of the novel contrast agents that have been tested in patients and discuss the need for larger, multi-center patient studies to fully validate the applicability of new imaging ...
Source: Current Cardiovascular Imaging Reports - Category: Radiology Source Type: research

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Source: American Heart Journal - Category: Cardiology Source Type: research
Abstract Coronary heart disease (CHD) remains a major cause of mortality with a huge economic burden on healthcare worldwide. Here, we conducted a systematic review to investigate the efficacy and safety of Chinese herbal medicine (CHM) for CHD based on high-quality randomized controlled trials (RCTs) and summarized its possible mechanisms according to animal-based researches. 27 eligible studies were identified in eight database searches from inception to June 2018. The methodological quality was assessed using seven-item checklist recommended by Cochrane Collaboration. All the data were analyzed using Rev-Man 5....
Source: Pharmacological Reviews - Category: Drugs & Pharmacology Authors: Tags: Front Pharmacol Source Type: research
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Source: Anaesthesia and intensive care medicine - Category: Anesthesiology Source Type: research
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Source: WebMD Health - Category: Consumer Health News Source Type: news
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Source: Canadian Journal of Diabetes - Category: Endocrinology Source Type: research
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Source: Circulation - Category: Cardiology Authors: Tags: Circulation Source Type: research
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Source: Guardian Unlimited Science - Category: Science Authors: Tags: Medical research Heart attack Heart disease Science Society UK news Source Type: news
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Source: International Journal of Cardiology - Category: Cardiology Authors: Tags: Editorial Source Type: research
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Source: Drugs.com - Daily MedNews - Category: General Medicine Source Type: news
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Source: Value in Health Regional Issues - Category: International Medicine & Public Health Source Type: research
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