B subset cells in patients with chronic granulomatous disease in a Mexican population.
This study was performed in a Latin American cohort.
RESULTS: We found significantly higher levels of naive B cells and B1a cells, but lower levels of memory B cells were found in CGD patients compared to HC. There was no significant difference of cell percentages per inheritance type.
DISCUSSION: Our findings suggest that the deficiency of NADPH oxidase components can affect the differentiation of naive B cells to memory B cells. Consequently, memory cells will be low, which also influenced the expression of CD27 in memory B cells and as a result, the percentage of naive cells increases. An altered phenotype of B lymphocytes in CGD patients may contribute to the opportunistic infections and autoimmune disorders that are seen in this disease.
PMID: 31176517 [PubMed - as supplied by publisher]
Source: Allergologia et Immunopathologia - Category: Allergy & Immunology Authors: Beltrán-Pozo CF, Suárez-Gutiérrez MA, Yamazaki-Nakashimada MA, Medina-Vera I, Saracho-Weber F, Macías-Robles AP, Guzmán-Martínez MN, Navarrete-Rodríguez EM, Del Río-Navarro BE, Espinosa-Padilla SE, Blancas-Galicia L Tags: Allergol Immunopathol (Madr) Source Type: research