Glycolytic activation of peritumoral monocytes fosters immune privilege via the PFKFB3-PD-L1 axis in human hepatocellular carcinoma

Monocytes/macrophages constitute a major component of most solid tumors and exhibit great plasticity and diversity according to different environmental cues.1 –3 Instead of inducing anti-tumor immune responses, monocytes/macrophages can be educated by the tumor microenvironment and facilitate disease progression via diverse mechanisms.4,5 For example, we and others have found that the peritumoral stroma of human hepatocellular carcinoma (HCC) is highly infiltrated by monocytes with activated phenotypes.
Source: Journal of Hepatology - Category: Gastroenterology Authors: Source Type: research