Glycolytic activation of peritumoral monocytes fosters immune privilege via the PFKFB3-PD-L1 axis in human hepatocellular carcinoma
Monocytes/macrophages constitute a major component of most solid tumors and exhibit great plasticity and diversity according to different environmental cues.1 –3 Instead of inducing anti-tumor immune responses, monocytes/macrophages can be educated by the tumor microenvironment and facilitate disease progression via diverse mechanisms.4,5 For example, we and others have found that the peritumoral stroma of human hepatocellular carcinoma (HCC) is highly infiltrated by monocytes with activated phenotypes.
Source: Journal of Hepatology - Category: Gastroenterology Authors: Dong-Ping Chen, Wan-Ru Ning, Ze-Zhou Jiang, Zhi-Peng Peng, Ling-Yan Zhu, Shi-Mei Zhuang, Dong-Ming Kuang, Limin Zheng, Yan Wu Source Type: research
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