Reduction of immunosuppressive tumor microenvironment in cholangiocarcinoma by ex-vivo targeting immune checkpoint molecules

Liver cancer is the second most common cause of cancer-related mortality worldwide.[1] Cholangiocarcinoma (CCA) accounts for 10% of primary liver cancers and the incidence is significantly increasing. CCA is an aggressive hepatobiliary malignancy originating from the biliary tract epithelium with features of cholangiocyte differentiation.[2] It is classified into the following types according to its anatomic location along the biliary tree: intrahepatic (iCCA), perihilar (pCCA) and distal (dCCA).
Source: Journal of Hepatology - Category: Gastroenterology Authors: Source Type: research

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Source: Cancer Management and Research - Category: Cancer & Oncology Tags: Cancer Management and Research Source Type: research
Tumor burden is an important factor in defining prognosis among patients with primary and secondary liver cancers. Although the eighth edition of the American Joint Committee on Cancer staging system has changed the criteria for staging patients with intrahepatic cholangiocarcinoma to better define the effect of tumor burden on prognosis, the impact of intrahepatic cholangiocarcinoma tumor burden on overall survival has not been examined using a machine-learning tool.
Source: Surgery - Category: Surgery Authors: Source Type: research
Cancer Biotherapy and Radiopharmaceuticals, Ahead of Print.
Source: Cancer Biotherapy and Radiopharmaceuticals - Category: Cancer & Oncology Authors: Source Type: research
Partial hepatectomy is the first option for intrahepatic mass-forming cholangiocarcinoma (IMCC) treatment, which would prolong survival. The main reason for the poor outcome after curative resection is the hig...
Source: Cancer Imaging - Category: Radiology Authors: Tags: Research article Source Type: research
Abstract Cholangiocarcinoma (CCA) is the second most common hepatobiliary cancer after hepatocellular carcinoma. Antiangiogenic therapy has been administered to patients with CCA, but the benefits of this therapy remain unsatisfactory. Improved understanding of the molecular mechanisms underlying angiogenesis in CCA is required. In the present study, the expression of GATA‑binding protein 6 (GATA6), lysyl oxidase‑like 2 (LOXL2) and vascular endothelial growth factor A (VEGFA), in addition to the microvessel density (MVD), were evaluated by performing immunohistochemical stain...
Source: International Journal of Oncology - Category: Cancer & Oncology Authors: Tags: Int J Oncol Source Type: research
Authors: Saijuntha W, Sithithaworn P, Kiatsopit N, Andrews RH, Petney TN Abstract Clonorchis sinensis, Opisthorchis viverrini, and O. felineus are liver flukes of human and animal pathogens occurring across much of Europe and Asia. Nevertheless, they are often underestimated compared to other, better known neglected diseases in spite of the fact that many millions of people are infected and hundreds of millions are at risk. This is possibly because of the chronic nature of the infection and disease and that it takes several decades prior to a life-threatening pathology to develop. Several studies in the past decade...
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
ConclusionsEarly surgery that reduces the operative delay after PBD may improve both short ‐ and long‐term postoperative outcomes in cancer patients undergoing PBD.This article is protected by copyright. All rights reserved.
Source: Journal of Hepato-Biliary-Pancreatic Sciences - Category: Gastroenterology Authors: Tags: Original Article Source Type: research
Cancers, Vol. 11, Pages 926: Wnt/β-Catenin Signaling in Liver Cancers Cancers doi: 10.3390/cancers11070926 Authors: Wenhui Wang Ron Smits Haiping Hao Chaoyong He Liver cancer is among the leading global healthcare issues associated with high morbidity and mortality. Liver cancer consists of hepatocellular carcinoma (HCC), cholangiocarcinoma (CCA), hepatoblastoma (HB), and several other rare tumors. Progression has been witnessed in understanding the interactions between etiological as well as environmental factors and the host in the development of liver cancers. However, the pathogenesis remains poorly ...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Review Source Type: research
To investigate risk factors for extrahepatic cholangiocarcinoma (ECC) in China. A total of 200 ECC cases and 200 matched control were included in the study. The presence of cigarette smoking, alcohol drinking, choledocholithiasis, primary sclerosing cholangitis, liver fluke infection (Clonorchis sinensis), diabetes mellitus, was investigated through clinical records. Blood from all cases was tested for hepatitis B surface antigen. Odds ratios (OR) and 95% confidence intervals (CIs) were estimated using conditional logistic regression. Compared with controls, ECC patients had a higher prevalence of cigarette smoking (61.0 v...
Source: European Journal of Cancer Prevention - Category: Cancer & Oncology Tags: Research Papers: Gastrointestinal Cancer Source Type: research
ConclusionMGMT may play a critical role in carcinogenesis and the development of ICC, and provides a new marker of clinical prognosis and target for ICC treatment.
Source: Clinical and Translational Oncology - Category: Cancer & Oncology Source Type: research
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