Loss of Fbxw7 synergizes with activated AKT signaling to promote c-Myc dependent cholangiocarcinogenesis

Cholangiocarcinoma (CCA) is the second most common primary liver cancer [1,2]. Depending on the anatomical site, CCA is classified into intrahepatic (iCCA) and extrahepatic cholangiocarcinoma (eCCA) [3]. iCCA incidence has been rising over the last decade, while that of eCCA slightly decreased [4]. For iCCA detected at early stage, curative surgical resection is the optimal treatment strategy [5,6]. However, less than one third of patients achieves negative tumor margins, and recurrence rate is high [5,7].

Source: Journal of Hepatology - June 9, 2019 Category: Gastroenterology Authors: Jingxiao Wang, Haichuan Wang, Michele Peters, Ning Ding, Silvia Ribback, Kirsten Utpatel, Antonio Cigliano, Frank Dombrowski, Meng Xu, Xinyan Chen, Xinhua Song, Li Che, Matthias Evert, Antonio Cossu, John Gordan, Yong Zeng, Xin Chen, Diego F. Calvisi Source Type: research