Resistance Reversed in KatG Mutants of Mycobacterium tuberculosis.

Resistance Reversed in KatG Mutants of Mycobacterium tuberculosis. Trends Microbiol. 2019 Jun 05;: Authors: Machado P, Bizarro CV, Basso LA Abstract A peptidomimetic containing a thiazolo ring-fused 2-pyridone (C10) has now been reported to inhibit hypoxia-induced tolerance to isoniazid (INH) in Mycobacterium tuberculosis (Flentie et al., Proc. Natl. Acad. Sci. U. S. A., 2019). The C10 compound could also potentiate the bactericidal activity in aerobically grown bacilli, prevented selection of drug-resistant strains, and reversed INH resistance in katG (catalase-peroxidase) mutants. PMID: 31176512 [PubMed - as supplied by publisher]
Source: Trends in Microbiology - Category: Microbiology Authors: Tags: Trends Microbiol Source Type: research