Structurally related glucosylated liposomes: Correlation of physicochemical and biological features

Publication date: Available online 10 June 2019Source: Biochimica et Biophysica Acta (BBA) - BiomembranesAuthor(s): Alessandro Mauceri, Luisa Giansanti, Giuseppina Bozzuto, Maria Condello, Agnese Molinari, Luciano Galantini, Antonella Piozzi, Giovanna ManciniAbstractLiposomes functionalized on their surface with carbohydrates (glycoliposomes) represent an optimal approach for targeting of drugs to diseased tissues in vivo, thanks to biocompatibility, low toxicity and easy manufacturing of these lipid nanoparticles. Here we report on the study of liposomes including a novel glycosylated amphiphile and on the comparison of their features with those of glycosylated analogues described previously. Further, the capability of the different glucosylated formulations to interact with three breast cancer cell lines was investigated. Our results show that the hydrophobic portion of the lipid bilayer strongly influences both the properties and the internalization of glycosylated liposomes.Graphical abstract
Source: Biochimica et Biophysica Acta (BBA) Biomembranes - Category: Biochemistry Source Type: research