Immunotherapy delays type 1 diabetes, study finds

Drug delays diabetes onset a median of 2 years Related items fromOnMedica Statin use link to heightened type 2 diabetes risk in some people Type 2 diabetes drugs vary in impact on survival NICE approves extra ‘triple therapy’ drug for diabetes Study claims medical treatment can reverse type 2 diabetes Drug could cut heart events by 26% in diabetics
Source: OnMedica Latest News - Category: UK Health Source Type: news

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Conclusion: Meta-analyses of all glucose-lowering RCTs involving patients with diabetes provide precise estimates of benefits for CHD and major cardiovascular events after consideration of the resulting ongoing BP difference. No benefit or harm on mortality, heart failure and stroke were noticed, while discontinuations related to adverse events because of treatment were increased following glucose-lowering. The extent of glucose-lowering is proportionally related to changes of CHD and stroke composite, and treatment-related discontinuations.
Source: Journal of Hypertension - Category: Cardiology Tags: REVIEWS AND META-ANALYSES Source Type: research
ConclusionsLow-GI diets may be useful for glycemic control and may reduce body weight in people with prediabetes or diabetes.
Source: American Journal of Clinical Nutrition - Category: Nutrition Source Type: research
CONCLUSIONS: Low-GI diets may be useful for glycemic control and may reduce body weight in people with prediabetes or diabetes. PMID: 31374573 [PubMed - as supplied by publisher]
Source: The American Journal of Clinical Nutrition - Category: Nutrition Authors: Tags: Am J Clin Nutr Source Type: research
Abstract Many drugs with anti-diabetic effects regulate glucose consumption in peripheral tissues. Via cellular glucose consumption assays, we identified that coptisine, a main effective constituent from the plant Coptis chinensis, enhanced hepatic and skeletal muscle glucose consumption. We further explored its effects on glucose metabolism in diabetic animals to elucidate its mechanism of action. Our results showed that coptisine did not show cytotoxicity. Intragastric administration of coptisine for ten days in normal ICR mice markedly decreased fasting blood-glucose levels without significant effects on body w...
Source: European Journal of Pharmacology - Category: Drugs & Pharmacology Authors: Tags: Eur J Pharmacol Source Type: research
Large international study explores role of dulaglutide Related items fromOnMedica Statin use link to heightened type 2 diabetes risk in some people Diabetes prescriptions rise by a third in last five years US expert group updates statins recommendations Drug could cut heart events by 26% in diabetics Metformin doesn ’t help HbA1c in teens with type 1 diabetes
Source: OnMedica Latest News - Category: UK Health Source Type: news
Sarah K. Azzam1, Wael M. Osman2, Sungmun Lee1, Kinda Khalaf1, Ahsan H. Khandoker1, Wael Almahmeed3,4, Herbert F. Jelinek5 and Habiba S. Al Safar1,2* 1Biomedical Engineering Department, Khalifa University of Science and Technology, Abu Dhabi, United Arab Emirates 2Khalifa University Center of Biotechnology, Abu Dhabi, United Arab Emirates 3Institute of Cardiac Science, Sheikh Khalifa Medical City, Abu Dhabi, United Arab Emirates 4Heart and Vascular Institute, Cleveland Clinic, Abu Dhabi, United Arab Emirates 5Australian School of Advanced Medicine, Sydney and School of Community Health, Charles Sturt University, Ma...
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
Alessandro Poggi1*, Roberto Benelli2, Roberta Venè1, Delfina Costa1, Nicoletta Ferrari1, Francesca Tosetti1 and Maria Raffaella Zocchi3 1Molecular Oncology and Angiogenesis Unit, IRCCS Ospedale Policlinico San Martino, Genoa, Italy 2Immunology Unit, IRCCS Ospedale Policlinico San Martino, Genoa, Italy 3Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy It is well established that natural killer (NK) cells are involved in both innate and adaptive immunity. Indeed, they can recognize molecules induced at the cell surface by stress signals ...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
In conclusion, TSF improved lipid accumulation and hepatic steatosis by inducing the AMPK/SIRT1 pathway-mediated autophagy. Introduction Nonalcoholic fatty liver disease (NAFLD) has become a worldwide health concern due to the increased incidence of obesity and diabetes. In addition, NAFLD is closely associated with the risk factors of coronary heart disease, such as metabolic syndrome, diabetes mellitus, and dyslipidemia, which are considered to be the leading causes of death (Wiest et al., 2017). Although our understanding of the pathogenesis of NAFLD has significantly improved, there is still no effective medica...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
This study aimed to compare the effect of high-intensity interval training (HIIT) with moderate-intensity continuous training (MCT) on endothelial function, oxidative stress and clinical fitness in patients with type 1 diabetes. Thirty-six type 1 diabetic patients (mean age 23.5 ± 6 years) were randomized into 3 groups: HIIT, MCT, and a non-exercising group (CON). Exercise was performed in a stationary cycle ergometers during 40 min, 3 times/week, for 8 weeks at 50–85% maximal heart rate (HRmax) in HIIT and 50% HRmax in MCT. Endothelial function was measured by flow-mediated dilation (FMD) [endothelium-depende...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
This study was hypothesis-driven; the genetic variants were selected for being previously and substantially genotyped. The big sample size and the rich panel of other biomarkers allowed the authors to conduct much more detailed analyses on this topic. The third article by Provenzi et al. proposed their perspectives on the role of telomeres in premature birth and discussed the potential implications for early adversity and care in the neonatal intensive care unit (Pavanello et al.). Indeed, the speculation of telomeres in aging begins in the premature aging syndrome. It is thus interesting to examine if telomeres also play...
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
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