Whooping Cough Vaccine Effectiveness Fades With Time: Study

Source: Pulmonary Medicine News - Doctors Lounge - Category: Respiratory Medicine Tags: Family Medicine, Infections, Pediatrics, Pulmonology, News, Source Type: news

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Authors: Ring N, Abrahams JS, Bagby S, Preston A, MacArthur I Abstract The evolution of Bordetella pertussis from a common ancestor similar to Bordetella bronchiseptica has occurred through large-scale gene loss, inactivation and rearrangements, largely driven by the spread of insertion sequence element repeats throughout the genome. B. pertussis is widely considered to be monomorphic, and recent evolution of the B. pertussis genome appears to, at least in part, be driven by vaccine-based selection. Given the recent global resurgence of whooping cough despite the wide-spread use of vaccination, a more thorough unde...
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
Authors: Lambert EE, Buisman AM, van Els CACM Abstract Pertussis remains endemic in vaccinated populations due to waning of vaccine-induced immunity and insufficient interruption of transmission. Correlates of long-term protection against whooping cough remain elusive but increasing evidence from experimental models indicates that the priming of particular lineages of B. pertussis (Bp) specific CD4+ T cells is essential to control bacterial load. Critical hallmarks of these protective CD4+ T cell lineages in animals are suggested to be their differentiation profile as Th1 and Th17 cells and their tissue residency. ...
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
This study reports the first extensive proteome analysis of this bacterium. In an attempt to gain some insight into the infective phenotype, we evaluated the response of B. parapertussis to iron starvation, a critical stress the bacteria face during infection. Among other relevant findings, we observed that the adaptation to this condition involves significant changes in the abundance of two important virulence factors of this pathogen, namely, adenylate cyclase and the O-antigen. We further used the proteomic data to search for B. parapertussis proteins that are absent or classified as pseudogenes in the genome of Bordete...
Source: Journal of Proteomics - Category: Biochemistry Authors: Tags: J Proteomics Source Type: research
Humboldt County has a pertussis vaccination rate of more than 90 percent, but health officials are urging anyone who has not received the booster vaccination to get it immediately.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
[Vaccine rejection and vaccination management: the grey areasRecusa vacinal e gestão da imunização: nuances e contrastes]. Rev Panam Salud Publica. 2019;43:e54 Authors: Hortal M, Di Fabio JL Abstract Vaccinating children has been an unquestioned tradition for many years. However, there is now great concern over the growing rejection of childhood vaccination, as well as other less evident obstacles that affect vaccination coverage.Multiple factors are involved in the rejection of a specific vaccine or vaccination in general, including actions by anti-vaccination groups, as well as d...
Source: Pan American Journal of Public Health - Category: International Medicine & Public Health Tags: Rev Panam Salud Publica Source Type: research
Conclusion: Whooping cough is a cause of morbidity and mortality, especially in those younger than 6 months of age and in those who are not immunized or only partially immunized. Vaccination rates should be improved and case confirmation encouraged to prevent the underdiagnosis of this disease.
Source: Revista Brasileira de Terapia Intensiva - Category: Intensive Care Source Type: research
Legislators trying to curb the numbers of unvaccinated children have been met with vigorous opposition from upset parents.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Vaccination and Immunization Children and Childhood Parenting Freedom of Religion Whooping Cough Medicine and Health Measles Law and Legislation Mumps Epidemics Advisory Committee on Immunization Practices Centers for Disease Control Source Type: news
Christina Hildebrand went down a rabbit hole and emerged at the statehouse in Sacramento. That’s how she describes it–going down a rabbit hole–and in her case it happened 14 years ago, when she was pregnant with her first child. In a world filled with chemicals and toxins, processed foods and GMOs, she decided her baby would be brought up as naturally and chemical-free as possible. It was when she was researching how best to achieve that goal that she bumped into vaccines. That was a bad time to begin thinking about such things. The fraudulent 1998 paper by British physician Andrew Wakefield ostensibly li...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized vaccines Source Type: news
The researchers said that the findings show the importance of keeping up to date on a child's shots, and the critical need to develop new and better vaccines against whooping cough.
Source: WebMD Health - Category: Consumer Health News Source Type: news
The modern vaccine for whooping cough becomes less effective as children age, a new study shows, highlighting the need for new vaccines to protect children against the highly contagious disease.
Source: CNN.com - Health - Category: Consumer Health News Source Type: news
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