Merck to buy Tilos Therapeutics in deal valued at up to $773 million

Merck&Co. Inc, in its second megadeal involving a cancer therapy developer in as many months, entered into a definitive agreement Monday to acquire Tilos Therapeutics in a transaction valued up to $773 million. Tilos, based in Lexington, Mass., is a biopharmaceutical company that has developed a portfolio of new drug candidates that employ a novel approach to modulating the potent signaling molecule known as TGFβ. TGFβ is believed to play an important role in the development of cancer and fibrotic…
Source: Health Care:Pharmaceuticals headlines - Category: Pharmaceuticals Authors: Source Type: news

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Source: Kevin, M.D. - Medical Weblog - Category: General Medicine Authors: Tags: Physician Oncology/Hematology Source Type: blogs
This study investigated the prevalence of depression and explored fatigue, QOL, and pain that is associated with depression in patients on first admission to a hematologic oncology unit. METHODS: This descriptive study measured depression, QOL, and fatigue with the Patient Health Questionnaire-9, the Functional Assessment of Cancer Therapy (FACT)-General, and the FACT-Anemia scale, respectively. Pain levels were examined with a numeric rating scale. FINDINGS: 58 patients participated; 17 reported moderate to severe depression, which highly correlated with fatigue, QOL, and pain. Among all factors, multivariate an...
Source: Clinical Journal of Oncology Nursing - Category: Nursing Authors: Tags: Clin J Oncol Nurs Source Type: research
This study elucidates the potential to use mitochondria from different donors (PAMM) to treat UVR stress and possibly other types of damage or metabolic malfunctions in cells, resulting in not only in-vitro but also ex-vivo applications. Gene Therapy in Mice Alters the Balance of Macrophage Phenotypes to Slow Atherosclerosis Progression Atherosclerosis causes a sizable fraction of all deaths in our species. It is the generation of fatty deposits in blood vessel...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
In conclusion, PARP1/2 inhibitors decrease the ubiquitination of ALC1 leading to the accumulation of ALC1, which affects the therapeutic effects of DNA damage response drugs in breast cancer treatment. PMID: 31322269 [PubMed - as supplied by publisher]
Source: Oncology Reports - Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
This study therefore, sought to determine the effect of Photodynamic Therapy (PDT) in eradicating cervical cancer and cervical CSCs. Cervical CSCs were isolated from a cervical adenocarcinoma cell line, HeLa cells, and grown in liquid medium incubated at 37° C, 5% CO2 and 85% humidity. Increasing doses of AlPcSmix photosensitizer were administered to both the total cell population and the isolated CSCs, and irradiated using 673.2 nm diode laser. Post-irradiation cellular changes were observed using biochemical assays and microscopy to determine the response of both the total cell population and the CSCs. Results showed...
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
Chem. Commun., 2019, Accepted Manuscript DOI: 10.1039/C9CC04098F, Feature ArticleJinggong Liu, Haoqiang Lai, Zushuang Xiong, Bolai Chen, Tianfeng Chen The successful clinical application of the three generation platinum anticancer drugs, cisplatin, carboplatin and oxaliplatin, has promoted research interest in metallodrugs; however, the problems of drug resistance and adverse effects... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - Category: Chemistry Authors: Source Type: research
Publication date: November 2019Source: Materials Science and Engineering: C, Volume 104Author(s): Yu-Liang Lai, Yu-Mei Cheng, Shiow-Kang YenAbstractThe doxorubicin-chitosan composite is deposited electrochemically on the Ti alloy post hydroxyapatite coated for reducing the side effects by sustaining release of drugs localized near the tumor to achieve the inhibition or apoptosis of cancer. The possibility of danger in case of exfoliation of medicine composite and HA agglomerates from the alloy surface due to the dynamic erosion of blood flow could be overcome with the additional surface modification by the electrochemical ...
Source: Materials Science and Engineering: C - Category: Materials Science Source Type: research
AbstractBackgroundImmune checkpoint inhibitors, single or in combination, have recently become a cornerstone for the treatment of many malignancies. Ipilimumab, a CTLA-4 inhibitor, was initially FDA approved for treatment of unresectable or metastatic melanoma and subsequently in combination therapy for other cancers. Ipilimumab-induced hypophysitis (IH) risk of development varies in different studies between 0 and 17%. Furthermore, little is known on how to predict which patients will develop IH and its impact on efficacy of Ipilimumab and survival for these patients. Here we reviewed IH and its impact on progression-free...
Source: Pituitary - Category: Endocrinology Source Type: research
Augusto Orlandi Breast cancer is the most common form of tumor in women and the leading cause of cancer-related mortality. Even though the major cellular burden in breast cancer is constituted by the so-called bulk tumor cells, another cell subpopulation named cancer stem cells (CSCs) has been identified. The latter have stem features, a self-renewal capacity, and the ability to regenerate the bulk tumor cells. CSCs have been described in several cancer types but breast cancer stem cells (BCSCs) were among the first to be identified and characterized. Therefore, many efforts have been put into the phenotypic character...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Review Source Type: research
Publication date: Available online 18 July 2019Source: Chinese Chemical LettersAuthor(s): Lingzhi Ma, Tianfeng Yang, Zeyuan Zhang, Siping Yin, Zhongxiao Song, Wen Shi, Dake Chu, Yanmin Zhang, Mingming ZhangAbstractIn this work, a near-infrared emissive dipyridyl ligand was synthesized and used to prepare three platinum(II) metallacycles with different shapes via metal-coordination-driven self-assembly with different platinum(II) precursors. These metallacycles were further used for both cell imaging and cancer therapy, offering a new type of theranostic agents towards cancer treatment.Graphical Abstract
Source: Chinese Chemical Letters - Category: Chemistry Source Type: research
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