Prognostic value and association with epithelial-mesenchymal transition and molecular subtypes of the proteoglycan biglycan in advanced bladder cancer.

CONCLUSION: BGN is an independent prognosticator for poor survival in BC patients. BGN is associated with the basal molecular BC subtype. EMT might be a key player for BGN driven oncogenesis, as BGN expression correlates with EMT gene signatures.
PMID: 31176613 [PubMed - as supplied by publisher]

Source: Urologic Oncology - June 4, 2019 Category: Urology & Nephrology Authors: Schulz GB, Grimm T, Sers C, Riemer P, Elmasry M, Kirchner T, Stief CG, Karl A, Horst D Tags: Urol Oncol Source Type: research