Extracellular lipid loading augments hypoxic paracrine signaling and promotes glioma angiogenesis and macrophage infiltration.

CONCLUSIONS: Together, these data identify extracellular lipid loading as a potentially targetable modulator of the paracrine adaptive response in the hypoxic tumor niche and suggest the contribution of the distinct lipid loaded phenotype in shaping the glioma microenvironment.
PMID: 31174567 [PubMed - in process]

Source: Clin Med Res - June 6, 2019 Category: Research Authors: Offer S, Menard JA, Pérez JE, de Oliveira KG, Chandran VI, Johansson MC, Bång-Rudenstam A, Siesjö P, Ebbesson A, Hedenfalk I, Sundgren PC, Darabi A, Belting M Tags: J Exp Clin Cancer Res Source Type: research