Challenges and opportunities for drug delivery to the posterior of the eye.

Challenges and opportunities for drug delivery to the posterior of the eye.
Drug Discov Today. 2019 Jun 05;:
Authors: Cabrera FJ, Wang DC, Reddy K, Acharya G, Shin CS
Abstract
Drug delivery to the posterior of the eye remains challenging even though the eye is readily accessible. Its unique and complex anatomy and physiology contribute to the limited drug delivery via non-invasive topical treatment, which is the prevalent ophthalmic treatment. To treat the most common retinal diseases, intravitreal (IVT) injection has been a common and effective therapy. With the advancement of nanotechnologies, novel formulations and drug delivery systems are being developed to treat posterior diseases. Here, we discuss the recent advancement in ocular delivery systems, including-sustained release formulations, IVT implants, and preclinical topical formulations, and the challenges faced in clinical translations.
PMID: 31175955 [PubMed - as supplied by publisher]

Source: Drug Discovery Today - June 4, 2019 Category: Drugs & Pharmacology Authors: Cabrera FJ, Wang DC, Reddy K, Acharya G, Shin CS Tags: Drug Discov Today Source Type: research