An unusual presentation of invasive aspergillosis after lung transplantation
Cattelan AM, Loy M, Tognon S, Rea F, Sasset L, Cadrobbi P
Fungal infections are an important cause of mortality and morbidity in lung transplant recipients, and Aspergillus species are the most common cause of infection. Comprehensive consensus guidelines on antifungal prophylaxis against Aspergillus infection in lung transplant recipients has not been established. There are clinical practice variations in Aspergillus prophylaxis, with regards to duration of treatment, choice of agent, and route of administration. Voriconazole is the agent mostly used as Aspergillus prophylaxis.
Conclusion: Our study has contributed to understand the interaction response of human lung epithelial cells during A. terreus infection. Also, our study may facilitate the identification of inflammatory biomarker against A. terreus.
Conclusions. ISV is widely used in hematological pts with IFI also in diseases other than acute myeloid leukemia and it is overall well tolerated. ORR to ISV is at least comparable with other antifungal agents. A rec/ref underlying hematological disease impacts both on OS and response to ISV, while having an IFI refractory to other antifungal agents including azoles does not seem to compromise the response to ISV, although this promising result should be confirmed in prospective studies and larger groups of patients.DisclosuresBusca: Gilead: Honoraria, Membership on an entity's Board of Directors or advisory committees, Sp...
We report a case of Paragonimus westermani infection simultaneously affecting two separate organs that presented as both a pulmonary cavity and adrenal mass in an immunocompromised host.A 65-year-old male with a previous kidney transplant visited our clinic because of hemoptysis. Forty-three months earlier, bilateral spontaneous pneumothorax was diagnosed and treated with oxygen supplementation and right chest tube insertion. At that time, there was no demonstrable cavitary lesion in either lung and no mass in the adrenal glands (Fig. 1A, 1B). Computed tomography (CT) of the chest when the patient presented with hemoptysis...
ConclusionsIsolation of NTM or Aspergillus species from lung transplant recipients is uncommon. Adequate pre-transplant control and post-transplant management of NTM and Aspergillus infections allows for safe lung transplantation.
We present a case of primary Aspergillus appendicitis diagnosed by histologic examination in a patient who underwent lung transplantation.
We studied cytokine patterns predictive of subsequent invasive aspergillosis (IA) in lung transplant recipients (LTRs) with Aspergillus spp (Asp) colonization post-transplant.
We report a case of successful treatment of probable invasive pulmonary aspergillosis due to A. lentulus and polymicrobial infection with Pseudomonas aeruginosa in a patient with relapsing granulomatosis with polyangiitis and recent high-dose steroid therapy.
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Invasive pulmonary aspergillosis (IPA) is a life-threatening lung disease of hematological malignancy or bone marrow transplant patients caused by the ubiquitous environmental fungus Aspergillus fumigatus. Current diagnostic tests for the disease lack sensitivity as well as specificity, and culture of the fungus from invasive lung biopsy, considered the gold standard for IPA detection, is slow and often not possible in critically ill patients. In a previous study, we reported the development of a novel non-invasive procedure for IPA diagnosis based on antibody-guided positron emission tomography and magnetic resonance imag...