Genetic diversity of HLA system in a population from Guerrero, Mexico.

Genetic diversity of HLA system in a population from Guerrero, Mexico. Hum Immunol. 2019 Jun 04;: Authors: Juárez-Nicolás F, Barquera R, Martínez-Álvarez JC, Hernández-Zaragoza DI, Ortega-Yáñez A, Arrieta-Bolaños E, Clayton S, Bravo-Acevedo A, Arrazola-García MA, Immel A, Juárez-Barreto V, Benítez-Arvizu G, Vega-Martínez MDR, García-Álvarez R, Martínez-Bezies V, Escutia-González AB, Díaz-López R, Guizar-López GU, Salgado-Galicia N, Zúñiga J, Yunis EJ, Bekker-Méndez C, Granados J Abstract We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 144 Mexicans from the state of Guerrero to obtain information regarding allelic and haplotypic frequencies. We find that the ten most frequent haplotypes in the state of Guerrero include eight Native American and two European haplotypes. Admixture estimates revealed that the main genetic components in the state of Guerrero are Native American (61.36 ± 2.69% by ML; 54.17% of Native American haplotypes) and European (35.01 ± 4.59% by ML; 32.29% of European haplotypes), and a relatively low African genetic component (3.63 ± 2.38% by ML; 5.90% of African haplotypes). PMID: 31174910 [PubMed - as supplied by publisher]
Source: Human Immunology - Category: Allergy & Immunology Authors: Tags: Hum Immunol Source Type: research