Genetic diversity of HLA system in two populations from Michoac án, Mexico: Morelia and rural Michoacán.

Genetic diversity of HLA system in two populations from Michoacán, Mexico: Morelia and rural Michoacán. Hum Immunol. 2019 Jun 04;: Authors: Ballesteros-Romero M, Barquera R, Rodríguez-López ME, Hernández-Zaragoza DI, Goné-Vázquez I, Clayton S, Arrieta-Bolaños E, Escobedo-Ruíz A, Pantoja-Torres JA, García-Arias VE, Arellano-Prado FP, Bravo-Acevedo A, Sánchez-Fernández MGJ, Sandoval-Sandoval MJ, Gómez-Navarro B, Zúñiga J, Yunis EJ, Bekker-Méndez C, Granados J, Acuña-Alonzo V Abstract We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 498 Mexicans from the state of Michoacán living in the city of Morelia (N = 150) and rural communities (N = 348), to obtain information regarding allelic and haplotypic frequencies. We find that the ten most frequent haplotypes found in the state of Michoacán include 12 Native American and two European haplotypes. Admixture estimates revealed that the main genetic components in the state of Michoacán are Native American (48.79 ± 1.44%) and European (43.10 ± 0.86%), while African genetic component is less apparent (8.11 ± 0.85%). Our findings add to the growing knowledge on the population genetics of Western Mexico and provide new HLA data on populations from Michoacán. PMID: 31174912 [PubMed - as supplied by publisher]
Source: Human Immunology - Category: Allergy & Immunology Authors: Tags: Hum Immunol Source Type: research