Loxapine, An Antipsychotic Drug, Suppresses Intracellular Multiple-Antibiotic-Resistant Salmonella enterica Serovar Typhimurium in Macrophages

ConclusionAltogether, our data suggested that loxapine might suppress intracellular bacteria through inhibiting of bacterial efflux pumps. In light of its unique activity, loxapine represents a promising lead compound with translational potential for the development of a new antibacterial agent against intracellular bacteria.
Source: Journal of Microbiology, Immunology and Infection - Category: Microbiology Source Type: research

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Publication date: Available online 22 October 2019Source: Biosensors and BioelectronicsAuthor(s): Mohammed Sedki, Xingyu Chen, Chuan Chen, Xin Ge, Ashok MulchandaniAbstractA highly sensitive and selective non-lytic M13 phage-based electrochemical impedance spectroscopy (EIS) cytosensor for early detection of coliforms is introduced for the first time. AuNPs were electrochemically deposited on the surface of glassy carbon electrode, and the M13 phage particles were immobilized on them using 3-mercaptopropanoic acid linker and zero-length crosslinking chemistry (EDC/NHS). Next, the sensor surface was blocked to avoid non-spe...
Source: Biosensors and Bioelectronics - Category: Biotechnology Source Type: research
The objective of this study was to determine the carrying of STEC in Paraguayan bovines and to analyze the virulence profile and serotypes of these isolates. A total of 197 samples of bovine fecal samples and an average of 5 to 50 colonies from stx1/stx2 positive samples were studied. The stx1, stx2, saa, ehxA and eae genes were amplified by PCR. 84.8% of the cattle were carriers of STEC. The predominant virulence profiles were stx2 and stx2/saa/ehxA. The serotyping was performed by agglutination reactions for 60 selected isolates, resulting in isolation of serogroup O103, which could produce infections in humans. This wor...
Source: Revista Argentina de Microbiologia - Category: Microbiology Tags: Rev Argent Microbiol Source Type: research
Publication date: 15 January 2020Source: Catalysis Today, Volume 340Author(s): Sami Rtimi, John KiwiAbstractThis review focuses on the acceleration of the bactericidal and fungicidal effects by uniform, adhesive Cu-based nanocomposites on textile and thin polymer surfaces. The acceleration of the bacterial inactivation kinetics mediated by Cu, TiO2/Cu and ZrO2-TiO2-Cu films in aerobic and anaerobic media is discussed for Gram negative, Gram positive bacteria and fungi. The Cu induced bacterial inactivation kinetics in the dark was observed to occur within the minute range for diverse bacteria. The characterization of the i...
Source: Catalysis Today - Category: Chemistry Source Type: research
Analyst, 2019, Accepted Manuscript DOI: 10.1039/C9AN01753D, PaperKunhao Qin, Dongfang Zhang, Yafang Ding, Xiaodan Zheng, Yingying Xiang, Jianhao Hua, Qi Zhang, Xiuling Ji, Bo Li, Yunlin Wei Carbon dots (CDs) has broad prospective applications in various fields, and expanding the applications of fluorescent CDs, especially for CDs derived from bacteria, is a major research goal. In this... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Analyst latest articles - Category: Chemistry Authors: Source Type: research
In this study, linear low density polyethylene (LLDPE) was melt mixed with GO nanoparticles having different oxidation and exfoliation degrees. Our results shown that the elastic modulus of LLDPE composites increased with the amount of GO, and by using highly oxidated GO this reinforcement effect was observed without reducing the elongation at break. The thermal stability of the composites under either inert and oxygen atmosphere also increased as compared with the pure matrix. Regarding the barrier properties, the oxygen permeability of the composites depended on the amount and kind of filler, and while GO with low oxidat...
Source: Composites Science and Technology - Category: Science Source Type: research
Conclusionpaying attention to the prevalence of infection with Staphylococcus epidermidis in this study and similar studies, with correct use of antibiotics for treatment and observation of hygiene principles in pediatrics and neonatal wards can reduce mortality and morbidity caused by the disease.
Source: Clinical Epidemiology and Global Health - Category: Epidemiology Source Type: research
In this study, the results showed that sub-MIC CAZ could significantly inhibit biofilm formation, swimming motility and the expression of the ibpA gene, while it could increase the expression of tnaA gene and extracellular indole concentration. Knockout of the ibpA gene resulted in a decrease in biofilm formation and swimming motility and an increase in the indole concentration. When treated with sub-MIC CAZ, the tnaA gene expression, indole concentration, biofilm formation and swimming motility of MG1655 ΔibpA were similar to those of the control group. The results indicated that sub-MIC CAZ might inhibit the biofil...
Source: Journal of Chemotherapy - Category: Cancer & Oncology Tags: J Chemother Source Type: research
Publication date: Available online 22 October 2019Source: Microbial PathogenesisAuthor(s): Chandran Sivasankar, Nisha Kumari Jha, Ruchira Ghosh, Prathapkumar Halady ShettyAbstractSalmonella enterica Typhi and Paratyphi A are food borne pathogens causing typhoid, which is one of the most important food borne disease in the developing world. S. Typhi and S. Paratyphi A are of much concern as multi drug resistance has been on the rise. The current study is aimed to screen phytochemicals for anti quorum sensing (QS) activity against S. Typhi and S. Paratyphi A. Upon screening with swarming assay, tannic acid (TA) showed highes...
Source: Microbial Pathogenesis - Category: Infectious Diseases Source Type: research
In this study, antimicrobial effects of a polypyrrole-carbon nanocomposite (PPy-C) upon laser irradiation in order to destroy the pathogenic gram-positive bacterium, methicillin-resistant Staphylococcus aureus (MRSA) were assessed. The bacterial cells were incubated with 500, 750 and 1000 μg ml-1 concentrations of PPy-C and irradiated with an 808-nm laser at a power density of 1.0 W cm-2. To indicate the biocompatibility and toxic effect of the nanocomposite without and with laser irradiation, the authors counted the number of CFUs and compared it to an untreated sample. Antibacterial mechanisms of PPy-C were assessed t...
Source: IET Nanobiotechnology - Category: Nanotechnology Source Type: research
Several materials such as silver are used to enhance graphene oxide (GO) sheets antimicrobial activity. However, these toxic materials decrease its biocompatibility and hinder its usage in many biological applications. Therefore, there is an urgent need to develop nanocomposites that can preserve both the antimicrobial activity and biocompatibility simultaneously. This work highlights the importance of functionalisation of GO sheets using Polyvinylpyrrolidone (PVP) and decorating them with silver nanoparticles (AgNPs) in order to enhance their antimicrobial activity and biocompatibility at the same time. The structural and...
Source: IET Nanobiotechnology - Category: Nanotechnology Source Type: research
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