Circulating rotaviral RNA in children with rotavirus antigenemia

Conclusions: Antigenemia is present in a significant number of patients with rotavirus diarrhea. Rotavirus viremia was absent in the children with rotavirus diarrhea who participated in our study, and was not indicated by the presence of antigenemia. The significance of circulating rotavirus antigen and genomic dsRNA in serum of patients with diarrhea deserves further study.
Source: Journal of Negative Results in BioMedicine - Category: Research Authors: Source Type: research

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Abstract Rotavirus A is a dynamically evolving pathogen causing acute gastroenteritis in children during the first years of life. In the present study, we conducted a phylodynamic analysis based on the complete sequences of 11 segments of rotaviruses with the G4P[8] and G2P[4] genotypes isolated in Russia in 2017. Since rotavirus has a segmented genome, our analysis was performed using the Bayesian approach based on separate samples of nucleotide sequences for each gene of the strains studied. For the strain with the genotype G4P[8], the most likely geographical locations of the nearest common ancestor were Russia (VP7, ...
Source: Virus Genes - Category: Genetics & Stem Cells Source Type: research
Conditions:   Pneumococcal Immunisation;   Diphtheria Immunisation;   Tetanus Immunisation;   Pertussis Immunisation;   Hepatitis B Immunisation;   Haemophilus Influenzae Type b Immunisation;   Polio Immunisation;   Measles Immunisation;   Rubella Immunisation;   Varicella Immunisation;   Mumps Immunisation Interventions:   Biological: SP0202-IIb Pneumococcal Conjugate Vaccine formulation 1;   Biological: SP0202-VI Pneumococcal Conjugate Vaccine formulation 2;   Biological: SP0202...
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
The objectives were to evaluate vaccine efficacy (VE) against RVGE of any-severity, severe RVGE (sRVGE) and inpatient caused by rotavirus serotypes contained in the vaccine and not contained in the vaccine after the third dose. Immunogenicity was also assayed in a subgroup. All adverse events (AEs) were collected from 30 min after each dose for immediate reaction, even to the entire study period, including the serious AEs (SAEs) and intussusception. RESULTS: VE against RVGE of any-severity, sRVGE and inpatient caused by any serotype was 56.6% (95% CI: 50.7, 61.8), 70.3% (95% CI: 60.6, 77.6) and 74.0% (95% CI: 57....
Source: Vaccine - Category: Allergy & Immunology Authors: Tags: Vaccine Source Type: research
Conditions:   Pneumococcal Immunisation;   Diphtheria Immunisation;   Tetanus Immunisation;   Pertussis Immunisation;   Hepatitis B Immunisation;   Haemophilus Influenzae Type b Immunisation;   Polio Immunisation;   Measles Immunisation;   Rubella Immunisation;   Varicella Immunisation;   Mumps Immunisation Interventions:   Biological: SP0202-IIb Pneumococcal Conjugate Vaccine formulation 1;   Biological: SP0202-VI Pneumococcal Conjugate Vaccine formulation 2;   Biological: SP0202...
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
This article aims to elucidate the possible role of cockroaches in food-borne infections by reviewing the relevant research publications. PMID: 32425541 [PubMed]
Source: Environmental Health Insights - Category: Environmental Health Authors: Tags: Environ Health Insights Source Type: research
Rotaviruses (RVs) are recognized as a major cause of acute gastroenteritis (AGE) in infants and young children worldwide. Here we summarize the virology, disease burden, prevalence, distribution of genotypes a...
Source: Journal of Biomedical Science - Category: Biomedical Science Authors: Tags: Review Source Type: research
Abstract Species A rotavirus (RVA) is an important gastrointestinal pathogen that is widely distributed in humans, mammalian animals and birds. The RVA genome consists of eleven double-stranded RNA segments, enabling the generation of novel strains with new pathogenic or antigenic features by genetic reassortment. While reassortants between human and mammalian animal RVAs have been repeatedly described, data on the reassortment potential of avian RVA strains are rare. To investigate genome segment exchanges between avian and mammalian RVA strains, a plasmid-based reverse genetics strategy originally developed for ...
Source: Virus Research - Category: Virology Authors: Tags: Virus Res Source Type: research
Authors: Tamminen K, Heinimäki S, Vesikari T, Blazevic V Abstract We have previously shown that rotavirus (RV) inner capsid protein VP6 has an adjuvant effect on norovirus (NoV) virus-like particle- (VLP-) induced immune responses and studied the adjuvant mechanism in immortalized cell lines used as antigen-presenting cells (APCs). Here, we investigated the uptake and presentation of RV VP6 and NoV GII.4 VLPs by primary bone marrow-derived dendritic cells (BMDCs). The adjuvant effect of VP6 on GII.4 VLP presentation and NoV-specific immune response induction by BMDC in vivo was also studied. Intracellular stai...
Source: Journal of Immunology Research - Category: Allergy & Immunology Tags: J Immunol Res Source Type: research
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Source: Gut Microbes - Category: Microbiology Authors: Source Type: research
AbstractAn unusual reassortant rotavirus A (RVA) strain was isolated during RVA surveillance in two previously hospitalized children in 2018. G/P typing revealed uncommon G9P[4] genotypes, so the strains were further characterized by Illumina next-generation sequencing. Whole-genome typing showed that the two strains had a DS-1-like backbone except for NSP2: G9-P[4]-I2-R2-C2-M2-A2-N1-T2-E2-H2. The two strains shared 99.9-100% nucleotide sequence identity in all genes.
Source: Archives of Virology - Category: Virology Source Type: research
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