Objective analysis of volume restoration in atrophic acne scars and skin pores: A split study using human stem cell-conditioned media.

In conclusion, HSCM may augment the regenerative effects of fractional CO2 laser. PMID: 31172821 [PubMed - as supplied by publisher]
Source: Journal of Dermatological Treatment - Category: Dermatology Tags: J Dermatolog Treat Source Type: research

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Conclusion: Topical SC-CM could potentially enhance the efficacy of FCL. However, PRP seems to be a better alternative. PMID: 31180258 [PubMed - as supplied by publisher]
Source: Journal of Dermatological Treatment - Category: Dermatology Tags: J Dermatolog Treat Source Type: research
Gulcin Tezcan1, Ekaterina V. Martynova1, Zarema E. Gilazieva1, Alan McIntyre2, Albert A. Rizvanov1 and Svetlana F. Khaiboullina1,3* 1Institute of Fundamental Medicine and Biology, Kazan Federal University, Kazan, Russia 2Centre for Cancer Sciences, Faculty of Medicine and Health Sciences, University of Nottingham, Nottingham, United Kingdom 3Department of Microbiology and Immunology, University of Nevada, Reno, Reno, NV, United States Inflammation has a crucial role in protection against various pathogens. The inflammasome is an intracellular multiprotein signaling complex that is linked to pathogen sensing and...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Conclusions In this review, we collected all the information concerning the OMICs studies performed on HS patients aimed at unraveling the mechanisms at the basis of the disease or associated to clinical severity and/or the successful response to pharmacological treatment (including biological drugs). The general picture of the OMICs contribution in the context of HS is not so clear and/or rich of clinical useful information, since most of the studies focused only on one aspect (genome, transcriptome, or proteome) of the disease, enrolling small numbers of patients (this is quite limiting for the genetic studies) from di...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Individual lesions in acne vulgaris exist spontaneous remission, which is related to shrunken and de-differential sebaceous gland (SGs) in comedone with unknown mechanisms. P. acnes stimulated by increased lipids from SGs plays key role in acne pathogenesis, while the relationship between the P. acnes and SGs is still a myth. We explored the action of P. acnes and peptidoglycan (PGN) on the effects of lipidgenesis and differentiation of cultured SZ95 human sebocytes. Firstly, we observed that both formaldehyde-inactivated P.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Skin, Appendages, and Stem Cell Biology Source Type: research
Acne is a chronic inflammatory skin disease thought to be driven by the activation of innate immune response to Cutibacterium acnes (C. acnes). However, the direct cause-and-effect relationship between the bacteria and the skin disease has been difficult to establish given that C. acnes is a ubiquitous skin commensal. Here, we investigated the mechanisms of how the immune system recognizes viable C. acnes and initiates the inflammatory response. Exposure of human peripheral blood mononuclear cells to of live C.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Skin, Appendages, and Stem Cell Biology Source Type: research
Authors: Surber C, Humbert P, Abels C, Maibach H Abstract Ninety years ago - in 1928, the term acid mantle was coined by the physicians Heinrich Schade and Alfred Marchionini in Kiel, Germany. A decade later Marchionini and several coworkers published 5 scientific communications in the Klinische Wochenschrift on "Der Säuremantel der Haut und Bakterienabwehr" (acid mantle and defense against bacteria). They described experimental detail, documented age- and body site as well as skin disease-dependent skin pH shifts, and discussed the significance of the pH and bacterial growth on the skin. In their fo...
Source: Current Problems in Dermatology - Category: Dermatology Tags: Curr Probl Dermatol Source Type: research
Propionibacterium acnes (P. acnes) is considered a contributing factor to the inflammation detected in follicles of patients with acne vulgaris. However, the ubiquitous distribution of P. acnes throughout the skin contrasts with the isolated occurrence of inflammatory lesions, leading to the hypothesis that the local environment and metabolic state of P. acnes may influence its interaction with the follicle. Under hypoxic conditions, P. acnes produces short-chain fatty acids (SCFAs) such as propionic or butyric acid, and we have previously shown that these SCFAs promote inflammatory gene expression by keratinocytes (Sci Immunol, 2016).
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Skin, Appendages, and Stem Cell Biology Source Type: research
This study was conducted to reveal the process of atrophic acne scar formation in histological and molecular views. Thirty subjects with acne were divided into two groups; fifteen were prone to acne scar (APS) and the others were not prone to acne scar (ANS). Skin samples of acne lesions were obtained on day 1, 3 and 7 after their onset. Elastic fibers, collagen 1 and collagen 3 were significantly decreased and their recovery was delayed in APS compared to those in ANS. On the other hand, the production of neutrophil elastase, matrix metalloproteinases (MMP)-1, MMP-2 and MMP-3 was substantially increased in APS compared to that in ANS.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Skin, Appendages, and Stem Cell Biology Source Type: research
Acne vulgaris is the most prevalent inflammatory skin disease in young age, however its immune pathogenesis is still being elucidated. Only few prior acne studies evaluated skin lesions, largely focusing on a limited panel of markers and/or lacking normal controls. The lack of comprehensive evaluations of all inflammatory axes involved in acne is hindering targeted-therapeutic development for acne. Our study profiles the molecular and cellular profiles of acne in mild-to-moderate patients (n=56), compared to aged-matched controls (n=20), using immunohistochemistry and gene expression studies on lesional, nonlesional, and h...
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Skin, Appendages, and Stem Cell Biology Source Type: research
Nicotinic acid (NA) is widely used in the clinical practice in treating dyslipidemias. Since NA influences lipid metabolism, and its side effects include skin dryness, we asked if it also impacts on the biology of sebocytes, the professional lipidogenic cells of the human skin. By using human, immortalized SZ95 sebocytes, we found that non-cytotoxic ( ≤100 μM; MTT, DilC1(5)-SYTOX Green) concentrations of NA had no effect on the basal sebaceous lipogenesis (SLP; Nile Red), but normalized several lipogenic agent (arachidonic acid, anandamide and linoleic acid+testosterone)-induced, excessive, acne-mimicking SLP in cour...
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Skin, Appendages, and Stem Cell Biology Source Type: research
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