Evidence-Based Medicine and the Problem of Healthy Volunteers.

Evidence-Based Medicine and the Problem of Healthy Volunteers. Ann Hepatol. 2017 Nov - Dec;16(6):832-834 Authors: Marchesini G, Marchignoli F, Petta S Abstract Healthy controls are subjects without the disease being studied but may have other conditions indirectly affecting outcome. In the present epidemics of obesity a few subjects with undiagnosed nonalcoholic fatty liver disease enter clinical studies as controls, producing biased results. Stricter selection criteria should be considered to prevent this risk. PMID: 31171322 [PubMed]

https://www.ncbi.nlm.nih.gov/pubmed/31171322?dopt=Abstract

Source: Annals of Hepatology - June 9, 2019 Category: Gastroenterology Tags: Ann Hepatol Source Type: research