Circulating blood cellular glucose transporters – Surrogate biomarkers for neonatal hypoxic-ischemic encephalopathy assessed by novel scoring systems

ConclusionCirculating RBC GLUT1 concentrations with NSE demonstrate a significant potential in reflecting the severity of HIE pre-TH and gauging effectiveness of TH. In contrast, the low neonatal WBC GLUT3 concentrations make discerning differences between degrees of HIE as well as assessing effectiveness of TH difficult. The HIE-high risk and Neurological scores may extend the “Sarnat staging” towards assessing severity and neuro-developmental prognosis of HIE.
Source: Molecular Genetics and Metabolism - Category: Genetics & Stem Cells Source Type: research