Network models of genome-wide association studies uncover the topological centrality of protein interactions in complex diseases.

CONCLUSION: Virtually all common diseases are complex human traits, and thus the topological centrality in protein networks of complex trait genes has implications in genetics, personal genomics, and therapy.
PMID: 23355459 [PubMed - as supplied by publisher]

Source: Journal of the American Medical Informatics Association - January 25, 2013 Category: Information Technology Authors: Lee Y, Li H, Li J, Rebman E, Achour I, Regan KE, Gamazon ER, Chen JL, Yang XH, Cox NJ, Lussier YA Tags: J Am Med Inform Assoc Source Type: research