Helicobacter pylori ( HP ) infection alone, but not HP -induced atrophic gastritis, increases the risk of gastric lymphoma: a case-control study in Japan

AbstractInfection withHelicobacter pylori (H.pylori) is associated with an increased risk of gastric malignant lymphoma. The chronic inflammation of gastric mucosa byH.pylori infection induces lymphomagenesis. Although this chronic mucosal inflammation also results in atrophic gastritis, evidence supporting the possible significance of atrophic gastritis in gastric lymphomagenesis is scarce. Here, to evaluate the association between gastric mucosal atrophy and the risk of gastric lymphoma, we conducted a matched case-control study at Aichi Cancer Center focusing on the attribution ofH.pylori infection status and pepsinogen (PG) serum levels. In total, 86 patients with gastric lymphoma (including 49 cases of extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) and 24 cases of diffuse large B cell lymphoma (DLBCL)) and 1720 non-cancer controls were included. Odds ratios (ORs) and 95% confidence intervals (CIs) were assessed by conditional logistic regression analysis with adjustment for potential confounders. Results failed to show a statistically significant association between atrophic gastritis and the risk of gastric lymphoma. The adjusted ORs of positive atrophic gastritis relative to negative for overall gastric lymphoma, MALT lymphoma, DLBCL, and other lymphomas were 0.77 (95% CI 0.45 –1.33), 0.65 (0.30–1.39), 1.03 (0.38–2.79), and 0.84 (0.22–3.29), respectively. In contrast, a positive association between overall gastric lymphom...
Source: Annals of Hematology - Category: Hematology Source Type: research