Early pregnancy biochemical markers of placentation for screening of gestational diabetes mellitus (GDM)

Publication date: Available online 8 June 2019Source: Diabetes &Metabolic Syndrome: Clinical Research &ReviewsAuthor(s): Sobia Alyas, Nabila Roohi, Samina Ashraf, Sadaf Ilyas, Azhar IlyasAbstractFor the effective management and screening of patients with diabetes, lipid profile has been a useful mean. Here, we hypothesized that biochemical analyses of blood serum in pregnant women with GDM will develop an insight on the pathogenesis of the disease and possibly uncover new biomarkers. In order to test our hypothesis, antenatal pregnant women (n = 300) were selected for blood samples including 176 with positive clinical/family history and 124 with negative clinical/family history of GDM during the early second trimester (14–18 weeks of gestation). All the subjects were followed up to the early third trimester (24–28 weeks of gestation) for second sampling until the onset of GDM. Lipid profile data shows that mean values of triglycerides, total cholesterol, low density lipids and very low density lipids were significantly higher (p 
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - Category: Endocrinology Source Type: research

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Publication date: July–August 2019Source: Diabetes &Metabolic Syndrome: Clinical Research &Reviews, Volume 13, Issue 4Author(s): Sobia Alyas, Nabila Roohi, Samina Ashraf, Sadaf Ilyas, Azhar IlyasAbstractFor the effective management and screening of patients with diabetes, lipid profile has been a useful mean. Here, we hypothesized that biochemical analyses of blood serum in pregnant women with GDM will develop an insight on the pathogenesis of the disease and possibly uncover new biomarkers. In order to test our hypothesis, antenatal pregnant women (n = 300) were selected for blood samples including 176 w...
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - Category: Endocrinology Source Type: research
This study aimed to compare the effect of high-intensity interval training (HIIT) with moderate-intensity continuous training (MCT) on endothelial function, oxidative stress and clinical fitness in patients with type 1 diabetes. Thirty-six type 1 diabetic patients (mean age 23.5 ± 6 years) were randomized into 3 groups: HIIT, MCT, and a non-exercising group (CON). Exercise was performed in a stationary cycle ergometers during 40 min, 3 times/week, for 8 weeks at 50–85% maximal heart rate (HRmax) in HIIT and 50% HRmax in MCT. Endothelial function was measured by flow-mediated dilation (FMD) [endothelium-depende...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
Conclusion The periconceptional environment and lifestyle factors modify sperm epigenome. This alteration might be maintained in the zygote and throughout development, thereby leading to the inheritance of newly acquired pathologies. The role of sperm miRNA, not only as innovative markers of fertility issues but also as vectors involved in the inheritance of paternal diseases, appears to be crucial. Overweight and obesity seem to alter sperm miRNA profile, thereby leading to transmission of different miRNA profiles in zygote, with consequences on embryo development. In long term, metabolic disorders have been described in...
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research
Mildren Porchas-Quijada1, Zyanya Reyes-Castillo1*, José Francisco Muñoz-Valle2, Sergio Durán-Barragán3,4, Virginia Aguilera-Cervantes1, Antonio López-Espinoza1, Mónica Vázquez-Del Mercado4, Mónica Navarro-Meza1 and Patricia López-Uriarte1 1Instituto de Investigaciones en Comportamiento Alimentario y Nutrición, Centro Universitario del Sur, Universidad de Guadalajara, Ciudad Guzmán, Mexico 2Instituto de Investigaciones en Ciencias Biomédicas, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Mexic...
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
by Jessica A. Grieger, Tina Bianco-Miotto, Luke E. Grzeskowiak, Shalem Y. Leemaqz, Lucilla Poston, Lesley M. McCowan, Louise C. Kenny, Jenny E. Myers, James J. Walker, Gus A. Dekker, Claire T. Roberts BackgroundObesity increases the risk for developing gestational diabetes mellitus (GDM) and preeclampsia (PE), which both associate with increased risk for type 2 diabetes mellitus (T2DM) and cardiovascular disease (CVD) in women in later life. In the general population, metabolic syndrome (MetS) associates with T2DM and CVD. The impact of maternal MetS on pregnancy outcomes, in nulliparous pregnant women, has not been invest...
Source: PLoS Medicine - Category: Internal Medicine Authors: Source Type: research
Conclusions: Although further confirmation is required, the findings from this study suggest that PFAS exposures during pregnancy may influence lipid metabolism and glucose tolerance and thus may impact the health of the mother and her child. https://doi.org/10.1289/EHP1062 Received: 7 September 2016 Revised: 5 October 2017 Accepted: 9 October 2017 Published: 13 November 2017 Address correspondence to M. Vrijheid, ISGlobal, Centre for Research in Environmental Epidemiology (CREAL), 88 Doctor Aiguader, 08003 Barcelona, Catalonia, Spain. Telephone: 93 214 73 46. Email: martine.vrijheid@isglobal.org Supplemental Material ...
Source: EHP Research - Category: Environmental Health Authors: Tags: Research Source Type: research
Time limit: 0 Quiz-summary 0 of 20 questions completed Questions: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 Information This test series requires login for attempting. You can login easily with your Facebook account (Use the CONNECT WITH icon on the upper part of right sidebar displaying t...
Source: Cardiophile MD - Category: Cardiology Authors: Tags: General Cardiology Source Type: blogs
This study was done to find out the prevalence of metabolic syndrome among newly diagnosed hypertensive patients in a tertiary care hospital of northern India, Guru Nanak Dev hospital, attached to Government Medical College, Amritsar, India.Methods: It is a hospital based cross sectional study involving one hundred newly diagnosed subjects with hypertension above the age 20 years. High blood pressure was defined according to Joint National committe-7 (JNC-7) guidelines, taking systolic BP> 140 and diastolic BP>90 as hypertension. Exclusion criteria included secondary hypertension, secondary cause of obesity, pregnanc...
Source: Hypertension - Category: Cardiology Authors: Tags: Poster Abstract Presentations Source Type: research
Conclusions: Population level of iAs% and DMA%, but not MMA%, were associated with arsenic exposure levels. Overall, study findings suggest that higher MMA% was associated with an increased risk of cancer and cardiovascular disease, while lower MMA% was associated with an increased risk of diabetes and metabolic syndrome. Additional population-based studies and experimental studies are needed to further evaluate and understand the role of arsenic exposure in arsenic metabolism and the role of arsenic metabolism in disease development. https://doi.org/10.1289/EHP577 Received: 01 June 2016 Revised: 26 February 2017 Acce...
Source: EHP Research - Category: Environmental Health Authors: Tags: Research Source Type: research
Conclusions: Follow-up of offspring will determine the potential long-term consequences of lower weight and adiposity at birth associated with prenatal PFAS exposure. https://doi.org/10.1289/EHP641 Received: 10 June 2016 Revised: 30 November 2016 Accepted: 13 December 2016 Published: 26 June 2017 Address correspondence to A. P. Starling, Dept. of Epidemiology, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, 12474 E. 19th Ave, Campus Box F426, Aurora, CO 80045 USA. Telephone: 303-724-8483. Email: anne.starling@ucdenver.edu Supplemental Material is available online (https://doi.org/10....
Source: EHP Research - Category: Environmental Health Authors: Tags: Research Source Type: research
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