Interleukin-22 receptor 1 is expressed in multinucleated giant cells: A study on intestinal tuberculosis and Crohn's disease.

Interleukin-22 receptor 1 is expressed in multinucleated giant cells: A study on intestinal tuberculosis and Crohn's disease. World J Gastroenterol. 2019 May 28;25(20):2473-2488 Authors: Yu ZQ, Wang WF, Dai YC, Chen XC, Chen JY Abstract BACKGROUND: It is challenging to distinguish intestinal tuberculosis from Crohn's disease due to dynamic changes in epidemiology and similar clinical characteristics. Recent studies have shown that polymorphisms in genes involved in the interleukin (IL)-23/IL-17 axis may affect intestinal mucosal immunity by affecting the differentiation of Th17 cells. AIM: To investigate the specific single-nucleotide polymorphisms (SNPs) in genes involved in the IL-23/IL-17 axis and possible pathways that affect susceptibility to intestinal tuberculosis and Crohn's disease. METHODS: We analysed 133 patients with intestinal tuberculosis, 128 with Crohn's disease, and 500 normal controls. DNA was extracted from paraffin-embedded specimens or whole blood. Four SNPs in the IL23/Th17 axis (IL22 rs2227473, IL1β rs1143627, TGFβ rs4803455, and IL17 rs8193036) were genotyped with TaqMan assays. The transcriptional activity levels of different genotypes of rs2227473 were detected by dual luciferase reporter gene assay. The expression of IL-22R1 in different intestinal diseases was detected by immunohistochemistry. RESULTS: The A allele frequency of rs2227473 (P = 0.030, odds ratio = 0.60, 95% confidence interval: 0.37-0.9...
Source: World Journal of Gastroenterology : WJG - Category: Gastroenterology Authors: Tags: World J Gastroenterol Source Type: research

Related Links:

Publication date: April 2020Source: Phytochemistry Letters, Volume 36Author(s): Fahd M. Abdelkarem, Ezz-Eldin K. Desoky, Alaa M. Nafady, Ahmed E. Allam, Aldoushy Mahdy, Maki Nagata, Tomofumi Miyamoto, Kuniyoshi ShimizuAbstractFurther chemical study of the crude extract of the soft coral Heteroxenia fuscescens (Fam., Xeniidea), led to isolation of two new sterols, Heterofuscesterols A (1) and B (2), a sterol isolated for the first time from natural sources, 3β,5α,6β-trihydroxyandrosta-17-one (3), along with one new hydroperoxy sesquiterpene, Heterofusceterpene A (4), and one known ceramide (5). Their structu...
Source: Phytochemistry Letters - Category: Chemistry Source Type: research
Publication date: Available online 21 February 2020Source: Chemical Engineering JournalAuthor(s): Meitong Ou, Chao Pan, Yongkang Yu, Xuan Wang, Yun Zhou, Hanjie Zhang, Qinzhen Cheng, Meiying Wu, Xiaoyuan Ji, Lin MeiAbstractExcessive reactive oxygen species (ROS), as effective cancer therapeutic agents, can promote tumor apoptosis. However, the clinical applications of ROS-mediated cancer therapies still have many limitations, such as self-defects of traditional photosensitizer, adverse tumor microenvironment (TME), and insufficient ROS production. Here, two-dimensional and highly oxidized ilmenite nanosheets (HOIL NSs, for...
Source: Chemical Engineering Journal - Category: Chemistry Source Type: research
Publication date: Available online 21 February 2020Source: Chemical Engineering JournalAuthor(s): Yang Zhang, Yanjun Xu, Di Sun, Zheying Meng, Weiwei Ying, Wei Gao, Rui Hou, Yuanyi Zheng, Xiaojun Cai, Bing Hu, Xianfang LinAbstractAs a promising treatment modality with spatial and temporal control, alternating magnetic field (AMF) triggered magnetic hyperthermal therapy (MHT) shows broad and promising applications to overcome the drawbacks of traditional focal therapies in combating cancer. However, the MHT efficacy is still not satisfactory with the presence of heat shock proteins (HSPs). In addition, sustained tumor hypox...
Source: Chemical Engineering Journal - Category: Chemistry Source Type: research
Chem. Commun., 2020, Accepted Manuscript DOI: 10.1039/D0CC00416B, CommunicationXinwei Tian, Zhao Li, Ning Ding, Jiahang Zhang We have developed a novel near-infrared ratiometric fluorescent theranostic nanoprobe. Reaction with glutathione, it would release a near-infrared fluorophore and chemotherapy drug. Notably, this nanoprobe can selectively kill cancer HeLa,... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - Category: Chemistry Authors: Source Type: research
Publication date: Available online 21 February 2020Source: MethodsXAuthor(s): Paul O'Brien, Christopher Vinnard, Selvakumar SubbianABSTRACTTuberculous meningitis (TBM), caused by Mycobacterium tuberculosis (Mtb), is the deadliest form of tuberculosis in humans, particularly in children and the geriatric population. However, the host-pathogen interactions underlying TBM is not well understood. Rabbits are a valuable model system to study TB in humans. The rabbit model of TB recapitulates several pathophysiological characteristics, including heterogeneity, architecture, and development of granulomas at the site of infection ...
Source: MethodsX - Category: Science Source Type: research
Conclusion: The findings, such as the inverse relationship with tuberculosis treatment discontinuation in the group of people with comorbidity, reinforce the importance of integrated actions in health services to change the scenario of this challenging comorbidity.
Source: Revista Brasileira de Epidemiologia - Category: Epidemiology Source Type: research
This article presents her outstanding character and most important lines of research. The focus of her studies covered alkylative and oxidative damage to DNA bases, in particular mutagenic and carcinogenic properties of purines with an open imidazole ring and 8-oxo-7,8-dihydroguanine (8-oxoGua). They also included analysis of mutagenic properties and pathways for the repair of DNA adducts of lipid peroxidation (LPO) products arising in large quantities during inflammation. Professor Tudek did all of this in the hope of deciphering the mechanisms of DNA damage removal, in particular by the base excision repair (BER) pathway...
Source: Mutation Research Genetic Toxicology and Environmental Mutagenesis - Category: Genetics & Stem Cells Source Type: research
ConclusionsBlood Metallothionein- 2A relative expression and oxidant status may have a prognostic value in breast cancer patients.
Source: Meta Gene - Category: Genetics & Stem Cells Source Type: research
Authors: Gok M, Sozuer E, Topal U, Akyuz M, Bozkurt GK, Hamurcu M, Deniz K Abstract Appendix vermiformis agenesis is quite rare. It is seen in 1/100,000 of patients who underwent laparotomy with an initial diagnosis of appendicitis. A 72-year-old woman who had not undergone any previous surgery was operated on for mechanical intestinal obstruction. Right hemicolectomy was performed due to obstructive tumoral mass in the hepatic flexure. There was no appendix vermiformis in exploration. Before deciding on the diagnosis of appendix agenesis, a thorough and rigorous exploration should be performed in ileocecal region ...
Source: Annali Italiani di Chirurgia - Category: Surgery Tags: Ann Ital Chir Source Type: research
Source: International Braz J Urol - Category: Urology & Nephrology Source Type: research
More News: Cancer | Cancer & Oncology | Colon Cancer | Colorectal Cancer | Crohn's Disease | Epidemiology | Gastroenterology | Gastrointestinal Polyps | Genetics | Inflammatory Bowel Disease | Polyps | Study | Tuberculosis