The safety evaluation of long-acting ocular delivery systems.

The safety evaluation of long-acting ocular delivery systems. Drug Discov Today. 2019 Jun 04;: Authors: Thackaberry EA, Lorget F, Farman C, Bantseev V Abstract The safety evaluation of ocular long-acting delivery (LAD) technologies is a nascent field. Here, we detail the challenges in assessing the safety of novel LAD technologies, and well as the most common types of toxicity encountered during early toxicity testing. A detailed understanding of the route of administration, pharmacology, and functionality and/or pharmacokinetics (PK) of LAD, along with all of its component parts, including the active pharmaceutical ingredient and excipients, is crucial for the successful development of next-generation long-acting ocular therapeutics. PMID: 31173909 [PubMed - as supplied by publisher]
Source: Drug Discovery Today - Category: Drugs & Pharmacology Authors: Tags: Drug Discov Today Source Type: research